Rab 25 is a small GTPase belonging to the RAS (rat sarcoma) superfamily. It is expressed in epithelial cells only and serves as a regulator of various intracellular signaling pathways. As a key player in in cell regulation, Rab 25 has been shown by research to function mainly as an oncogene in various cancers including breast cancer and ovarian cancer. However, Rab 25 has also been reported to be a tumor suppressor in cancer types such as colorectal cancer. A lot of research has been done about Rab 25 in recent years. This review is an overview of Rab 25, focusing on their role in human diseases such as cancer
10.1016/j.bbcan.2008.10.001Biochimica et Biophysica Acta - Reviews on Cancer17952110-116BBAC
AbstractSince their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of...
<p>The genes encoding the Ras family of small GTPases are mutated to yield constitutively active GTP...
Rab 25 is a small GTPase belonging to the RAS (rat sarcoma) superfamily. It is expressed in epitheli...
Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laborato...
Abstract The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups: ...
Transformation of epithelial cells is associated with loss of cell polarity, which includes alterati...
Abstract Background Ras-related protein 25 (Rab25) functions either as an oncogene or a tumor suppre...
Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in t...
Several studies have suggested that Ras-associated binding 25 protein (Rab25) is involved in the pat...
Rab25 can function as both a tumor suppressor and a tumor promoter across different tissues. This st...
Abstract Background The Rab27 family of small GTPases promotes the progression of breast cancer, mel...
Rab is a large subfamily of small GTPases which play an important role in multiple processes relatin...
The Rab27 subfamily of secretory small GTPase plays a vital role in vesicle trafficking and regulate...
The RAB guanosine triphosphates (RAS-related in brain) belong to the Ras superfamily of GTPases, and...
10.1016/j.bbcan.2008.10.001Biochimica et Biophysica Acta - Reviews on Cancer17952110-116BBAC
AbstractSince their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of...
<p>The genes encoding the Ras family of small GTPases are mutated to yield constitutively active GTP...
Rab 25 is a small GTPase belonging to the RAS (rat sarcoma) superfamily. It is expressed in epitheli...
Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laborato...
Abstract The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups: ...
Transformation of epithelial cells is associated with loss of cell polarity, which includes alterati...
Abstract Background Ras-related protein 25 (Rab25) functions either as an oncogene or a tumor suppre...
Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in t...
Several studies have suggested that Ras-associated binding 25 protein (Rab25) is involved in the pat...
Rab25 can function as both a tumor suppressor and a tumor promoter across different tissues. This st...
Abstract Background The Rab27 family of small GTPases promotes the progression of breast cancer, mel...
Rab is a large subfamily of small GTPases which play an important role in multiple processes relatin...
The Rab27 subfamily of secretory small GTPase plays a vital role in vesicle trafficking and regulate...
The RAB guanosine triphosphates (RAS-related in brain) belong to the Ras superfamily of GTPases, and...
10.1016/j.bbcan.2008.10.001Biochimica et Biophysica Acta - Reviews on Cancer17952110-116BBAC
AbstractSince their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of...
<p>The genes encoding the Ras family of small GTPases are mutated to yield constitutively active GTP...