Investigation of micro-RNAs as modulators of platelet reactivity: a translational approach

Platelet function (or reactivity) varies from one individual to another, a phenotype that is largely inherited and may be related to the recurrence of thrombotic events or the occurrence of bleeding events. Platelets are an abundant source of micro-ribonucleic acids (miRNAs) considered to be potential regulators of platelet function by a mechanism that remains unclear. The aim of this project is to functionally validate candidate miRNAs as regulators of platelet function and to study the underlying mechanisms with a translational approach. The combined analysis of the effect of miRNAs on platelet reactivity using a model of human hematopoietic stem cells and the results of a clinical association study (ADRIE) allow to a better understanding of the interaction of miRNAs on platelet function. The validated miRNAs could then be used as biomarkers to predict platelet reactivity and cardiovascular events or as therapeutic targets