Effect of vitamin D supplementation and muscular exercise on irisin serum level and related metabolic parameters in type II diabetic albino rats

Background and purpose: Irisin is a newly discovered myokine that reduces obesity and improves insulin resistance via the browning of white adipose tissues resulting in increased thermogenesis that promotes insulin sensitivity. The aim of this work was to detect the effect of Vitamin D and exercise on irisin expression in type II diabetic albino rats.Objective: The aim was to detect the effect of supplementation with Vitamin D and the role of exercise in improving type II diabetes, investigating their effects on irisn level.Design: This study was carried out on Fifty adult male albino rats which were divided into two main groups: Group I control in which the animals were fed on normal laboratory chow diet without exercise training. The remaining forty rats were used to establish type II diabetes, group IIA (n=10 rats) as diabetic control, group IIB (n=10 rats) exercised by swimming for 6 weeks, group IIC (n=10 rats) received vitamin D and group IID (n=10 rats) exercised and received vitamin D. Results: The results showed that exercise and vitamin D supplementation improved serum level of irisin, HOMA-IR and lipid profile (Cholesterol, LDL and triglycerides) in diabetic rats and the best effect was found with vitamin D administration in conjunction with exercise training Conclusion: Combined exercise training and vitamin D administration improved serum irisin level and lipid profile in diabetic albino rats that was reflected on insulin resistanc