Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by the inflammatory cytokine, IL-1β. Although IL-1β is known as the key driver of bone lesions in CRMO, the signaling events leading to pathogenic levels of the cytokine are not fully understood. Using a genetic mouse model of CRMO, Dasari et al. find a role for the nonreceptor spleen tyrosine kinase (SYK) in upstream signaling leading to IL-1β up-regulation. Their findings suggest that SYK may constitute a new therapeutic target for CRMO
Purpose of reviewChronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurre...
It has been widely believed that the cytokines required for osteoclast formation are M-CSF (also kno...
<p>Autoantibody production and autoantibody-mediated inflammation are hallmarks of a number of autoi...
ABSTRACT. Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder, covering a ...
Autoinflammatory syndromes are characterized by dysregulation of the innate immune response with sub...
Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonb...
The development of autoinflammatory diseases is caused by the dysregulation of innate immune mechani...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
The K/BxN serum transfer model of arthritis is critically dependent on FcγR signaling events mediate...
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease, and patients with acti...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
The immune system plays an important role in the pathophysiology of many acute and chronic bone diso...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
The K/BxN serum transfer model of arthritis is critically dependent on FcγR signaling events mediate...
Purpose of reviewChronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurre...
It has been widely believed that the cytokines required for osteoclast formation are M-CSF (also kno...
<p>Autoantibody production and autoantibody-mediated inflammation are hallmarks of a number of autoi...
ABSTRACT. Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder, covering a ...
Autoinflammatory syndromes are characterized by dysregulation of the innate immune response with sub...
Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonb...
The development of autoinflammatory diseases is caused by the dysregulation of innate immune mechani...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
The K/BxN serum transfer model of arthritis is critically dependent on FcγR signaling events mediate...
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease, and patients with acti...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
The immune system plays an important role in the pathophysiology of many acute and chronic bone diso...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
The K/BxN serum transfer model of arthritis is critically dependent on FcγR signaling events mediate...
Purpose of reviewChronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurre...
It has been widely believed that the cytokines required for osteoclast formation are M-CSF (also kno...
<p>Autoantibody production and autoantibody-mediated inflammation are hallmarks of a number of autoi...