Can Quantum Theory be Applied to the Universe as a Whole?

I argue that quantum theory can, and in fact must, be applied to the Universe as a whole. After a general introduction, I discuss two concepts that are essential for my chain of arguments: the universality of quantum theory and the emergence of classical behaviors by decoherence. A further motivation is given by the open problem of quantum gravity. I then present the main ingredients of quantum cosmology and discuss their relevance for the interpretation of quantum theory. I end with some brief epistemological remarks