Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we systematically analyzed the changes in gene expression associated with the progression of cartilage destruction in monoiodoacetate-induced arthritis (MIA) of the rat knee. Sprague Dawley female rats were given intra-articular injection of monoiodoacetate in the knee. The progression of MIA was monitored macroscopically, microscopically and by micro-computed tomography. Grade 1 damage was observed by day 5 post-monoiodoacetate injection, progressively increasing to Grade 2 by day 9, and to Grade 3-3.5 by day 21. Affymetrix GeneChip was utilized to analyze the transcriptome-wide changes in gene expression, and the expression of salient genes w...
SummaryObjectiveThe purpose of this study was to use microarray technology to: (1) understand the ea...
Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors including joi...
<div><p>Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors inclu...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
AbstractObjectives: To characterize the molecular events underlying cartilage injury in the early ph...
SummaryObjectiveThe objective of this study was to characterize the rat monosodium iodoacetate (MIA)...
AbstractObjectives: To characterize the molecular events underlying cartilage injury in the early ph...
SummaryObjectiveThe objective of this study was to characterize the rat monosodium iodoacetate (MIA)...
Objective. To analyze genome-wide changes in chondrocyte gene expression in a surgically induced mod...
SummaryObjectiveThe purpose of this study was to use microarray technology to: (1) understand the ea...
Abstract Background Osteoarthritis (OA) is a debilitating, progressive joint disease. Methods Simila...
SummaryObjectiveThe purpose of this study was to use microarray technology to: (1) understand the ea...
Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors including joi...
<div><p>Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors inclu...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis. Here, we...
AbstractObjectives: To characterize the molecular events underlying cartilage injury in the early ph...
SummaryObjectiveThe objective of this study was to characterize the rat monosodium iodoacetate (MIA)...
AbstractObjectives: To characterize the molecular events underlying cartilage injury in the early ph...
SummaryObjectiveThe objective of this study was to characterize the rat monosodium iodoacetate (MIA)...
Objective. To analyze genome-wide changes in chondrocyte gene expression in a surgically induced mod...
SummaryObjectiveThe purpose of this study was to use microarray technology to: (1) understand the ea...
Abstract Background Osteoarthritis (OA) is a debilitating, progressive joint disease. Methods Simila...
SummaryObjectiveThe purpose of this study was to use microarray technology to: (1) understand the ea...
Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors including joi...
<div><p>Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors inclu...