Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma
- Asgharzadeh, Shahab
- Salo, Jill A.
- Ji, Lingyun
- Oberthuer, Andre
- Fischer, Matthias
- Berthold, Frank
- Hadjidaniel, Michael
- Liu, Cathy Wei-Yao
- Metelitsa, Leonid S.
- Pique-Regi, Roger
- Wakamatsu, Peter
- Villablanca, Judith G.
- Kreissman, Susan G.
- Matthay, Katherine K.
- Shimada, Hiroyuki
- London, Wendy B.
- Sposto, Richard
- Seeger, Robert C.
Publication date
January 2012
DOI Publisher
American Society of Clinical Oncology (ASCO)Abstract
Purpose Children diagnosed at age >= 18 months with metastatic MYCN-nonamplified neuroblastoma (NBL-NA) are at high risk for disease relapse, whereas those diagnosed at age = 18 months had higher expression of inflammation-related genes than those in patients diagnosed at age 18 months with NBL-NA with a low-versus high-risk score was 47% versus 12%, 57% versus 8%, and 50% versus 20% in three independent clinical trials, respectively. Conclusion These data suggest that interactions between tumor and inflammatory cells may contribute to the clinical metastatic neuroblastoma phenotype, improve prognostication, and reveal novel therapeutic targets. J Clin Oncol 30:3525-3532. (C) 2012 by American Society of Clinical Oncolog
Add to ORKG