Background: Thymol is a phenolic compound used for its wide spectrum antimicrobial activity. There is a limited understanding of the antimicrobial mechanisms underlying thymol activity. To investigate this, E. coli strain JM109 was exposed to thymol at sub-lethal concentrations and after 16 rounds of exposure, isolates with a 2-fold increased minimal inhibitory concentration (MIC) were recovered (JM109-Thyr). The phenotype was stable after multiple sub-cultures without thymol. Results: Cell morphology studies by scanning electron microscopy (SEM) suggest that thymol renders bacterial cell membranes permeable and disrupts cellular integrity. 1H Nuclear magnetic resonance (NMR) data showed an increase in lactate and the lactic acid fam...
University of Minnesota Ph.D. dissertation. March 2013. Major: Biochemistry, Molecular Bio, and Biop...
One limitation of fluoropyrimidine chemotherapy is the sensitivity of normal host tissues to these d...
Antibiotic resistance is a growing problem on a global scale. Increasing numbers of bacteria resista...
Background: Thymol is a phenolic compound used for its wide spectrum antimicrobial activity. There i...
Thymol is a natural biocide and component of some essential oils from herbs. Its inhibitory effect o...
BACKGROUND: Targeting bacterial virulence factors is now gaining interest as an alternative strategy...
The continuous spread of antimicrobial resistance is endangering the efficient control of enterotoxi...
Thymol, carvacrol, and trans-cinnamaldehyde are essential oil (EO) compounds with broad-spectrum ant...
Drug-resistant variants of thymidylate synthase (TS) can poten-tially be used in gene therapy applic...
It is universally accepted that the use of antibiotics will lead to antimicrobial resistance. Tradit...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
BACKGROUND: Membrane permeability is the first step involved in resistance of bacteria to an antibio...
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to tre...
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of ...
There is convincing evidence that adaptation and survival processes in bacterial populations depend ...
University of Minnesota Ph.D. dissertation. March 2013. Major: Biochemistry, Molecular Bio, and Biop...
One limitation of fluoropyrimidine chemotherapy is the sensitivity of normal host tissues to these d...
Antibiotic resistance is a growing problem on a global scale. Increasing numbers of bacteria resista...
Background: Thymol is a phenolic compound used for its wide spectrum antimicrobial activity. There i...
Thymol is a natural biocide and component of some essential oils from herbs. Its inhibitory effect o...
BACKGROUND: Targeting bacterial virulence factors is now gaining interest as an alternative strategy...
The continuous spread of antimicrobial resistance is endangering the efficient control of enterotoxi...
Thymol, carvacrol, and trans-cinnamaldehyde are essential oil (EO) compounds with broad-spectrum ant...
Drug-resistant variants of thymidylate synthase (TS) can poten-tially be used in gene therapy applic...
It is universally accepted that the use of antibiotics will lead to antimicrobial resistance. Tradit...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
BACKGROUND: Membrane permeability is the first step involved in resistance of bacteria to an antibio...
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to tre...
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of ...
There is convincing evidence that adaptation and survival processes in bacterial populations depend ...
University of Minnesota Ph.D. dissertation. March 2013. Major: Biochemistry, Molecular Bio, and Biop...
One limitation of fluoropyrimidine chemotherapy is the sensitivity of normal host tissues to these d...
Antibiotic resistance is a growing problem on a global scale. Increasing numbers of bacteria resista...