Acute and chronic insufficient sleep are associated with adverse health outcomes and risk of accidents. There is therefore a need for biomarkers to monitor sleep debt status. None are currently available. We applied Elastic-net and Ridge regression to entire and pre-filtered transcriptome samples collected in healthy young adults during acute total sleep deprivation and following 1 week of either chronic insufficient (< 6 h) or sufficient sleep (~8.6 h) to identify panels of mRNA biomarkers of sleep debt status. The size of identified panels ranged from 9-74 biomarkers. Panel performance, assessed by leave-one-subject-out cross-validation and independent validation, varied between sleep debt conditions. Using between-subject assessme...
Inadequate sleep has become endemic, which imposes a substantial burden for public health and safety...
Copyright © 2015 Matthew S. Thimgan et al. This is an open access article distributed under the Crea...
There is general agreement within the sleep community and among public health officials of the need ...
Acute and chronic insufficient sleep are associated with adverse health outcomes and risk of acciden...
BACKGROUND: Although sleep deprivation is associated with neurobehavioral impairment that may underl...
This study tests the hypothesis that gene expression responds to total SD, and can be related to neu...
Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, inc...
Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, inc...
Background: Short or long sleep duration has been associated with some major chronic diseases, but w...
Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A ...
Diagnosis and treatment of circadian rhythm sleep-wake disorders requires assessment of circadian ph...
Background: The aim of this study was to discover significantly changed proteins in human blood seru...
<div><p>Inadequate sleep has become endemic, which imposes a substantial burden for public health an...
Inadequate sleep has become endemic, which imposes a substantial burden for public health and safety...
Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A ...
Inadequate sleep has become endemic, which imposes a substantial burden for public health and safety...
Copyright © 2015 Matthew S. Thimgan et al. This is an open access article distributed under the Crea...
There is general agreement within the sleep community and among public health officials of the need ...
Acute and chronic insufficient sleep are associated with adverse health outcomes and risk of acciden...
BACKGROUND: Although sleep deprivation is associated with neurobehavioral impairment that may underl...
This study tests the hypothesis that gene expression responds to total SD, and can be related to neu...
Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, inc...
Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, inc...
Background: Short or long sleep duration has been associated with some major chronic diseases, but w...
Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A ...
Diagnosis and treatment of circadian rhythm sleep-wake disorders requires assessment of circadian ph...
Background: The aim of this study was to discover significantly changed proteins in human blood seru...
<div><p>Inadequate sleep has become endemic, which imposes a substantial burden for public health an...
Inadequate sleep has become endemic, which imposes a substantial burden for public health and safety...
Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A ...
Inadequate sleep has become endemic, which imposes a substantial burden for public health and safety...
Copyright © 2015 Matthew S. Thimgan et al. This is an open access article distributed under the Crea...
There is general agreement within the sleep community and among public health officials of the need ...