Probing the diurnal regulation of glycemic control

Diurnal variation in human glycaemic control was reported by several authors in the 1960s. The classic study carried out by Jarrett and Keen giving oral glucose in the morning and evening established that increased glucose intolerance and insulin resistance occurs later in the day (Jarrett & Keen, 1969), a phenomenon often referred to as "afternoon diabetes". However, despite our long-standing knowledge of this phenomenon, its underlying mechanisms are still not well understood..