Preface, peer review declare, article: Formulation and Development of Grape Seed Oil (Vitis Vinifera L) Emulgel Peel-Off Mask using Gelling Agent Hydroxy Propyl Methyl Cellulose (HPMC)

Anti Aging dosage which form formulas that contain antioxidants are important to be developed. Grapeseed oil (GSO) has a higher antioxidant capacity than other parts of grapes at 42.18 mmol of Trolox equivalent/g. This study aims to develop a peel-off mask formula containing GSO in the emulgel system with Hydroxypropyl methyl cellulose (HPMC) as a gelling agent. Emulgel was made in four formulas (F1-F4) with 1-4% HPMC concentrations and one control formula (F0) of 3% HPMC without GSO. This was then evaluated for homogeneity and phase separation (centrifugation and freeze-thaw methods). Physical stability was observed during 28 days of storage with various parameters including organoleptic, pH, drying time, spreadability, viscosity, rheological flow, tensile strength, and elongation. The evaluation results showed that the emulgel was homogeneous and did not undergo phase separation by centrifuge and freeze-thaw. During the storage period, the five emulgel pH was within acceptable ranges, and there was no significant change in viscosity at 25C. Meanwhile, at 40°C, there was a trend of decreasing viscosity. Moreover, HPMC based GSO emulgel showed good physicochemical stability during the storage period at 25°C and 40°C for 4 weeks. In summary, the developed GSO emulgel are good candidates for topical peel-off mask in anti aging dosage form