This paper presents an interpretation of the ontology developed by Deleuze in Différence et répétition (1968) under a topological perspective. It maintains that the Deleuzian thesis concerning Being as univocal and differential is supported by a theory of expression which holds a conception of space that goes beyond the Euclidian viewpoint. I will approach this spatial dynamism from a series of mathematical notions that assist the production of Deleuze’s main ontological concepts, defining the expression and its moments by the interaction between different types of multiplicities, made of heterogeneous folds.Este artículo presenta una interpretación de la ontología desarrollada por Deleuze en Différence et répétition (1968) en clave topológ...