Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis.

Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up

Maxi Kaufmann
Rocco Haase
Undine Proschmann
Tjalf Ziemssen
Katja Akgün

December 2018

Natalizumab inhibits the transmigration of immune cells across the blood-brain barrier thus inhibiti...

Rudick, R. A.
Miller, D.
Hass, S.
Hutchinson, M
Calabresi, P. A.
Confavreux, C.
Galetta, S. L.
Giovannoni, G.
Havrdova, E.
Kappos, L.
Lublin, F. D.
Miller, D. H.
O'Connor, P. W.
Phillips, J. T.
Polman, C. H.
Radue, Ew
Stuart, W. H.
Wajgt, A.
Weinstock Guttman, B.
Wynn, D. R.
Lynn, F.
Panzara, M. A.
Affirm,
SENTINEL Investigators including: R., Macdonell
Hughes, A.
Taylor, I.
Lee, Y. C.
Ma, H.
King, J.
Kilpatrick, T.
Butzkueven, H.
Marriott, M.
Pollard, J.
Spring, P.
Spies, J.
Barnett, M.
Dehaene, I.
Vanopdenbosch, L.
D\u2019Hooghe, M.
Van Zandijcke, M.
Derijck, O.
Seeldrayers, P.
Jacquy, J.
Piette, T.
De Cock, C.
Medaer, R.
Soors, P.
Vanroose, E.
Vanderhoven, L.
D\u2019Hooghe, M.
Nagels, G.
Dubois, B.
Deville, M. C.
D\u2019Haene, R.
Jacques, F.
Hall\ue9, D.
Gagnon, S.
Likavcan, E.
Murray, T. J.
Bhan, V.
Mackelvey, R.
Maxner, C. E.
Christie, S.
Giaccone, R.
Guzman, D. A.
Melanson, M.
Esfahani, F.
Gomori, A. J.
Nagaria, M. H.
Grand\u2019Maison, F.
Berger, L.
Nasreddine, Z.
Duplessis, M.
Brunet, D.
Melanson, M.
Jackson, A.
Pari, G.
O\u2019Connor, P.
Gray, T.
Hohol, M.
Marchetti, P.
Lee, L.
Murray, B.
Sahlas, J.
Perry, J.
Devonshire, V.
Hooge, J.
Hashimoto, S.
Oger, J.
Smyth, P.
Rice, G.
Kremenchutzky, M.
Stourac, P.
Kadanka, Z.
Benesova, Y.
Niedermayerova, I.
Meluzinova, E.
Marusic, P.
M,
Bojar,
Zarubova, K.
Houzvickov\ue1, E.
Pikov\ue1, J.
Talab, R.
Faculty, Hospital Olomouc
Olomouc, B. Muchova
Urb\ue1nek, K
Kettnerova, Z.
Mares, J.
Otruba, P.
Zapletalov\ue1, O.
Hradilek, P.
Ddolezil, D. Dolezil
Woznicova, I.
H\uf6fer, R.
Ambler J. Fiedler, Z. Ambler J. Fiedler
Sucha, J.
Matousek, V.
Rektor, I.
Dufek, M.
Mikulik, R.
Mastik, J.
Tyrlikova, I.
General, Teaching Hospital
Prague, E. Havrdov\ue1
Horakova, D.
Kalistov\ue1, H.
T\ufdblov\ue1, M.
Ehler, E.
Novotn\ue1, A.
Geier, P.
Soelberg Sorensen, P.
Ravnborg, M.
Petersen, B.
Blinkenberg, M.
F\ue4rkkil\ue4, M.
Harno, H.
Kallela, M.
H\ue4pp\uf6l\ue4, O.
Elovaara, I.
Kuusisto, H.
Ukkonen, M.
Peltola, J.
Palmio, J.
Pelletier, J.
Feuillet, L.
Suchet, L.
Dalecky, A.
Tammam, D.
Edan, G.
Le Page, E.
M\ue9rienne, M.
Yaouanq, J.
Clanet, M.
Mekies, C.
Azais Vuillemin, C.
Senard, A.
Lau, G.
Steinmetz, G.
Warter V. Wolff, J. Warter V. Wolff
Fleury, M.
Tranchant, C.
Stark, E.
Buckpesch Heberer, U.
Henn, K. H.
Skoberne, T.
Schimrigk, S.
Hellwig, K.
Brune, N.
Weiller, C.
Gbadamosi, J.
R\uf6ther, J.
Heesen, C.
Buhmann, C.
Karageorgiou, C.
Korakaki, D.
Giannoulis, D. r.
Tsiara, S.
Thomaides, T.
Thomopoulos, I.
Papageorgiou, H.
Armakola, F.
Komoly, S.
R\uf3zsa, C.
Matolcsi, J.
Szab\uf3, G. y.
Moln\ue1r, B.
Lovas, G.
Dioszeghy, P.
Szulics, P.
Magyar, Z.
Incze, J.
Farkas, J.
Clemens, B.
K\ue1nya, J.
Valicsk\uf3, Z. s.
Bense, E.
Nagy, Z. s.
Ger\ue9by, G.
Per\ue9nyi, J.
Simon, Z. s.
Szapper, M.
Gedeon, L.
Csanyi, A.
Rum, G.
Lip\uf3th, S.
Szegedi, A.
J\ue1vor, L.
Nagy, I.
Ad\ue1m, I.
Szirmai, I.
Sim\uf3, M.
Ertsey, C.
I,
Amrein,
Kamondi, A.
Harcos, P.
Dobos, E.
Szab\uf3, B.
Balas, V.
Guseo, A.
Fodor, E.
J\uf3fej\ufc, E.
Eizler, K.
Csiba, L.
Cs\ue9p\ue1ny, T.
Pallagi, E.
Bereczki, D.
Jakab, G.
Juh\ue1sz, M.
Bszab\uf3, B. Szab\uf3 I. Mayer
Katona, G.
Hutchinson, M.
O\u2019Dwyer, J.
O\u2019Rourke, K.
Sanders, E. A. C. M.
Rijk van Andel, J. F.
Bomhof, M. A. M.
van Erven, P.
Hintzen I. Hoppenbrouwers, R. Q. Hintzen I. Hoppenbrouwers
Neuteboom, R. F.
Zemel, D.
van Doorn, P. A.
Jacobs, B. C.
Munster, E. T. h. L. Van
ter Bruggen, J. P.
Bernsen, R.
Jongen, P. J. H.
de Smet, E. A. A.
Tacken, H. F. H.
Polman, C.
Zwemmer, J.
Nielsen, J.
Kalkers, N.
Kragt, J.
Jasperse, B.
Willoughby, E.
Anderson, N. E.
Barber, A.
Anderson, T.
Parkin, P. J.
Fink, J.
Avery, S.
Mason, D.
Kwiecinski, H.
Zakrzewska Pniewska, B.
Kaminska, A.
Podlecka, A.
Nojszewska, M.
Czlonkowska, A.
Zaborski, J.
Wicha, W.
Kruszewska Ozimowska, J.
Darda Ledzion, L.
Selmaj, K.
Mochecka Thoelke, A.
Pentela Nowicka, J.
Walczak, A.
Stasiolek, M.
Stelmasiak, Z.
Bartosik Psujek, H.
Mitosek Szewczyk, K.
Belniak, E.
Chyrchel, U.
Wajgt, A.
Maciejowski, M.
Strzyzewska Lubos, L.
Lubos, L.
Matusik, E.
Maciejek, Z.
Niezgodzinska Maciejek, A.
Sobczynska, D.
Slotala, T.
Wawrzyniak, S.
Kochanowicz K. Kuczynski, J. Kochanowicz K. Kuczynski
Zimnoch, R.
Pryszmont, M.
Drozdowski, W.
Baniukiewicz, E.
Kulakowska, A.
Borowik, H.
Lewonowska, M.
Szczudlik, A.
R\uf3g, T.
Gryz Kurek, E.
Pankiewicz, J.
Furgal, J.
Kimkowicz, A.
Fryze, W.
Wierbicki, T.
Michalak, L.
Kowalewska, J.
Swiatkiewicz, J.
Hillert, J.
\uc5kesson, E
Fredrikson, S.
Diener, P
Olsson, T.
Wallstr\uf6m, E.
Fpiehl, F. Piehl L. Hopia
Brundin, L.
Marta, M.
Andersson, M.
Lycke, J.
Runmarker, B.
Malmestr\uf6m, C.
Vaghfeldt, P.
Skoog, B.
Schluep, M.
Bogousslavskyr, J.
Du Pasquier, R.
Kappos, L.
Achtnichts, L.
Kuhle, J.
Buitrago Telez, C.
Schl\ue4ger, R.
Naegelin, Y.
Eraksoy, M.
Bebek, N.
Akman Demir, G.
Topcuoglu, B.
Kurtuncu, M.
Istanbul, University
Istanbul:, A. Siva
Saip, S.
Altintas, A.
Kiyat, A.
Sharief, M.
Kasti, M.
Giovannoni, G.
Lim, E. T.
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LARONI, ALICE
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Cocco P. Marchi, E. Cocco P. Marchi
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MANCARDI, GIOVANNI LUIGI
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O\u2019Duffy, A.
Kita, M.
Taylor, L.
Elliott, M.
Roberts, J.
Jeffery, D.
Maxwell, S.
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de Vera, A.
Bacelar, O.
Kuster, P.
Kappos, L.

January 2007

Objective: To report the relationship between disease activity and health-related quality of life (H...

Design of TRUST, a non-interventional, multicenter, 3-year prospective study investigating an integrated patient management approach in patients with relapsing-remitting multiple sclerosis treated with natalizumab

Ziemssen, Tjalf
Gass, Hans-Joachim
Würfel, Jens
Bayas, Antonios
Tackenberg, Björn
Limmroth, Volker
Linker, Ralf
Mäurer, Mathias
Haas, Judith
Stangel, Martin
Meergans, Matthias
Harlin, Olof
Hartung, Hans-Peter

January 2016

Background: Natalizumab provides rapid and high-efficacy control of multiple sclerosis disease activ...

Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis

van Lierop, Zoë Y. GJ
Wieske, Luuk
Koel-Simmelink, Marleen J. A.
Chatterjee, Madhurima
Dekker, Iris
Leurs, Cyra E.
Willemse, Eline A. J.
Moraal, Bastiaan
Barkhof, Frederik
Eftimov, Filip
Uitdehaag, Bernhard M. J.
Killestein, Joep
Teunissen, Charlotte E.

January 2021

Background: Natalizumab treatment provides a model for non-inflammation-induced disease progression ...

Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis

van Lierop, Zoë Y. GJ
Noteboom, Samantha
Steenwijk, Martijn D.
van Dam, Maureen
Toorop, Alyssa A.
van Kempen, Zoé L. E.
Moraal, Bastiaan
Barkhof, Frederik
Uitdehaag, Bernard M. J.
Schoonheim, Menno M.
Teunissen, Charlotte E.
Killestein, Joep

December 2022

Background: Despite highly effective treatment strategies for patients with relapsing-remitting mult...

Serum Neurofilament Light Association With Progression in Natalizumab-Treated Patients With Relapsing-Remitting Multiple Sclerosis

Bridel, C
Leurs, CE
van Lierop, ZYGJ
van Kempen, ZLE
Dekker, I
Twaalfhoven, HAM
Moraal, B
Barkhof, F
Uitdehaag, BMJ
Killestein, J
Teunissen, CE

November 2021

OBJECTIVE: The objective of this study was to investigate the potential of serum neurofilament light...

Inflammatory Activity on Natalizumab Predicts Short-term but not Long-term Disability in Multiple Sclerosis

Raffel, J
Gafson, AR
Dahdaleh, S
Malik, O
Jones, B
Nicholas, R

January 2017

BACKGROUND: In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, ne...

Long-term disease activity and disability progression in relapsing-remitting multiple sclerosis patients on natalizumab

Dekker, I
Leurs, C E
Hagens, M H J
van Kempen, Z L E
Kleerekooper, I
Lissenberg-Witte, B I
Barkhof, F
Uitdehaag, B M J
Balk, L J
Wattjes, M P
Killestein, J

August 2019

BACKGROUND: Natalizumab is an effective treatment for relapsing-remitting multiple sclerosis (RRMS)....

Wearing-off at the end of natalizumab dosing interval and risk of MS disease activity: A prospective 1-year follow-up study

Bringeland, Gerd Haga
Myhr, Kjell-Morten
Vedeler, Christian A.
Gavasso, Sonia

January 2020

Natalizumab effectively prevents disease activity in relapsing-remitting multiple sclerosis by bindi...

Serum glial fibrillary acidic protein in natalizumab-treated relapsing-remitting multiple sclerosis: An alternative to neurofilament light

Wessels, Mark Hj
Van Lierop, Zoë YGJ
Noteboom, Samantha
Strijbis, Eva MM
Heijst, Johannes A
Van Kempen, Zoé LE
Moraal, Bastiaan
Barkhof, Frederik
Uitdehaag, Bernard MJ
Schoonheim, Menno M
Killestein, Joep
Teunissen, Charlotte E

September 2023

BACKGROUND: There is a need in Relapsing-Remitting Multiple Sclerosis (RRMS) treatment for biomarker...

Assessing disease activity in multiple sclerosis: biomarkers and clinical measures

Raffel, Joel Benjamin

May 2020

Background: Multiple sclerosis (MS) is the commonest cause of non-traumatic neurological disability ...

Brain-derived neurotrophic factor levels under chronic natalizumab treatment in multiple sclerosis. A preliminary report

Văcăraş, Vitalie
Major, Zoltán Zsigmond
Buzoianu, Anca Dana

January 1970

Aim of the study Our main purpose was to investigate if the chronic treatment with the disease-modif...

Inflammatory Activity on Natalizumab Predicts Short-Term but Not Long-Term Disability in Multiple Sclerosis

Raffel Joel
Gafson Arie R.
Dahdaleh Samer
Malik Omar
Jones Brynmor
Nicholas Richard

January 2017

In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesion...

Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy

Nováková Nyrén, Lenka

March 2018

The pathophysiology of multiple sclerosis (MS) is complex with the presence of inflammation and neur...

The effect of natalizumab on disability score and relapse rate of multiple sclerosis patients: a prospective cohort study

Mehrdokht Mazdeh
Shno Hosseini
Mohammad Taheri
Soudeh Ghafouri-Fard

November 2018

Abstract Multiple sclerosis (MS) is a progressive immune-related disorder of the central nervous sys...

Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up

Maxi Kaufmann
Rocco Haase
Undine Proschmann
Tjalf Ziemssen
Katja Akgün

December 2018

Natalizumab inhibits the transmigration of immune cells across the blood-brain barrier thus inhibiti...

Rudick, R. A.
Miller, D.
Hass, S.
Hutchinson, M
Calabresi, P. A.
Confavreux, C.
Galetta, S. L.
Giovannoni, G.
Havrdova, E.
Kappos, L.
Lublin, F. D.
Miller, D. H.
O'Connor, P. W.
Phillips, J. T.
Polman, C. H.
Radue, Ew
Stuart, W. H.
Wajgt, A.
Weinstock Guttman, B.
Wynn, D. R.
Lynn, F.
Panzara, M. A.
Affirm,
SENTINEL Investigators including: R., Macdonell
Hughes, A.
Taylor, I.
Lee, Y. C.
Ma, H.
King, J.
Kilpatrick, T.
Butzkueven, H.
Marriott, M.
Pollard, J.
Spring, P.
Spies, J.
Barnett, M.
Dehaene, I.
Vanopdenbosch, L.
D\u2019Hooghe, M.
Van Zandijcke, M.
Derijck, O.
Seeldrayers, P.
Jacquy, J.
Piette, T.
De Cock, C.
Medaer, R.
Soors, P.
Vanroose, E.
Vanderhoven, L.
D\u2019Hooghe, M.
Nagels, G.
Dubois, B.
Deville, M. C.
D\u2019Haene, R.
Jacques, F.
Hall\ue9, D.
Gagnon, S.
Likavcan, E.
Murray, T. J.
Bhan, V.
Mackelvey, R.
Maxner, C. E.
Christie, S.
Giaccone, R.
Guzman, D. A.
Melanson, M.
Esfahani, F.
Gomori, A. J.
Nagaria, M. H.
Grand\u2019Maison, F.
Berger, L.
Nasreddine, Z.
Duplessis, M.
Brunet, D.
Melanson, M.
Jackson, A.
Pari, G.
O\u2019Connor, P.
Gray, T.
Hohol, M.
Marchetti, P.
Lee, L.
Murray, B.
Sahlas, J.
Perry, J.
Devonshire, V.
Hooge, J.
Hashimoto, S.
Oger, J.
Smyth, P.
Rice, G.
Kremenchutzky, M.
Stourac, P.
Kadanka, Z.
Benesova, Y.
Niedermayerova, I.
Meluzinova, E.
Marusic, P.
M,
Bojar,
Zarubova, K.
Houzvickov\ue1, E.
Pikov\ue1, J.
Talab, R.
Faculty, Hospital Olomouc
Olomouc, B. Muchova
Urb\ue1nek, K
Kettnerova, Z.
Mares, J.
Otruba, P.
Zapletalov\ue1, O.
Hradilek, P.
Ddolezil, D. Dolezil
Woznicova, I.
H\uf6fer, R.
Ambler J. Fiedler, Z. Ambler J. Fiedler
Sucha, J.
Matousek, V.
Rektor, I.
Dufek, M.
Mikulik, R.
Mastik, J.
Tyrlikova, I.
General, Teaching Hospital
Prague, E. Havrdov\ue1
Horakova, D.
Kalistov\ue1, H.
T\ufdblov\ue1, M.
Ehler, E.
Novotn\ue1, A.
Geier, P.
Soelberg Sorensen, P.
Ravnborg, M.
Petersen, B.
Blinkenberg, M.
F\ue4rkkil\ue4, M.
Harno, H.
Kallela, M.
H\ue4pp\uf6l\ue4, O.
Elovaara, I.
Kuusisto, H.
Ukkonen, M.
Peltola, J.
Palmio, J.
Pelletier, J.
Feuillet, L.
Suchet, L.
Dalecky, A.
Tammam, D.
Edan, G.
Le Page, E.
M\ue9rienne, M.
Yaouanq, J.
Clanet, M.
Mekies, C.
Azais Vuillemin, C.
Senard, A.
Lau, G.
Steinmetz, G.
Warter V. Wolff, J. Warter V. Wolff
Fleury, M.
Tranchant, C.
Stark, E.
Buckpesch Heberer, U.
Henn, K. H.
Skoberne, T.
Schimrigk, S.
Hellwig, K.
Brune, N.
Weiller, C.
Gbadamosi, J.
R\uf6ther, J.
Heesen, C.
Buhmann, C.
Karageorgiou, C.
Korakaki, D.
Giannoulis, D. r.
Tsiara, S.
Thomaides, T.
Thomopoulos, I.
Papageorgiou, H.
Armakola, F.
Komoly, S.
R\uf3zsa, C.
Matolcsi, J.
Szab\uf3, G. y.
Moln\ue1r, B.
Lovas, G.
Dioszeghy, P.
Szulics, P.
Magyar, Z.
Incze, J.
Farkas, J.
Clemens, B.
K\ue1nya, J.
Valicsk\uf3, Z. s.
Bense, E.
Nagy, Z. s.
Ger\ue9by, G.
Per\ue9nyi, J.
Simon, Z. s.
Szapper, M.
Gedeon, L.
Csanyi, A.
Rum, G.
Lip\uf3th, S.
Szegedi, A.
J\ue1vor, L.
Nagy, I.
Ad\ue1m, I.
Szirmai, I.
Sim\uf3, M.
Ertsey, C.
I,
Amrein,
Kamondi, A.
Harcos, P.
Dobos, E.
Szab\uf3, B.
Balas, V.
Guseo, A.
Fodor, E.
J\uf3fej\ufc, E.
Eizler, K.
Csiba, L.
Cs\ue9p\ue1ny, T.
Pallagi, E.
Bereczki, D.
Jakab, G.
Juh\ue1sz, M.
Bszab\uf3, B. Szab\uf3 I. Mayer
Katona, G.
Hutchinson, M.
O\u2019Dwyer, J.
O\u2019Rourke, K.
Sanders, E. A. C. M.
Rijk van Andel, J. F.
Bomhof, M. A. M.
van Erven, P.
Hintzen I. Hoppenbrouwers, R. Q. Hintzen I. Hoppenbrouwers
Neuteboom, R. F.
Zemel, D.
van Doorn, P. A.
Jacobs, B. C.
Munster, E. T. h. L. Van
ter Bruggen, J. P.
Bernsen, R.
Jongen, P. J. H.
de Smet, E. A. A.
Tacken, H. F. H.
Polman, C.
Zwemmer, J.
Nielsen, J.
Kalkers, N.
Kragt, J.
Jasperse, B.
Willoughby, E.
Anderson, N. E.
Barber, A.
Anderson, T.
Parkin, P. J.
Fink, J.
Avery, S.
Mason, D.
Kwiecinski, H.
Zakrzewska Pniewska, B.
Kaminska, A.
Podlecka, A.
Nojszewska, M.
Czlonkowska, A.
Zaborski, J.
Wicha, W.
Kruszewska Ozimowska, J.
Darda Ledzion, L.
Selmaj, K.
Mochecka Thoelke, A.
Pentela Nowicka, J.
Walczak, A.
Stasiolek, M.
Stelmasiak, Z.
Bartosik Psujek, H.
Mitosek Szewczyk, K.
Belniak, E.
Chyrchel, U.
Wajgt, A.
Maciejowski, M.
Strzyzewska Lubos, L.
Lubos, L.
Matusik, E.
Maciejek, Z.
Niezgodzinska Maciejek, A.
Sobczynska, D.
Slotala, T.
Wawrzyniak, S.
Kochanowicz K. Kuczynski, J. Kochanowicz K. Kuczynski
Zimnoch, R.
Pryszmont, M.
Drozdowski, W.
Baniukiewicz, E.
Kulakowska, A.
Borowik, H.
Lewonowska, M.
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R\uf3g, T.
Gryz Kurek, E.
Pankiewicz, J.
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Kimkowicz, A.
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Michalak, L.
Kowalewska, J.
Swiatkiewicz, J.
Hillert, J.
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Fredrikson, S.
Diener, P
Olsson, T.
Wallstr\uf6m, E.
Fpiehl, F. Piehl L. Hopia
Brundin, L.
Marta, M.
Andersson, M.
Lycke, J.
Runmarker, B.
Malmestr\uf6m, C.
Vaghfeldt, P.
Skoog, B.
Schluep, M.
Bogousslavskyr, J.
Du Pasquier, R.
Kappos, L.
Achtnichts, L.
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Schl\ue4ger, R.
Naegelin, Y.
Eraksoy, M.
Bebek, N.
Akman Demir, G.
Topcuoglu, B.
Kurtuncu, M.
Istanbul, University
Istanbul:, A. Siva
Saip, S.
Altintas, A.
Kiyat, A.
Sharief, M.
Kasti, M.
Giovannoni, G.
Lim, E. T.
Rashid, W.
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Sharrack O. Suliman, B. Sharrack O. Suliman
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Nichol, P.
Barnes, D.
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Stoy, N.
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Rae Grant, A.
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Lo, A.
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Decoo, : D
Lampaert, J.
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Stenager, : E.
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Binzer, M.
Shorsh, K.
Christensen, M.
Ravnborg, M.
Soelberg S\uf8rensen, P.
Blinkenberg, M.
Petersen, B.
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Bech, E.
Petersen, T.
Kirkegaard, M.
Eralinna, : J.
Ruutiainen, J.
Soilu H\ue4nninen, M.
S\ue4k\uf6, E.
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Remes, A.
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Moreau, : T.
Noblet, M.
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Gout, O.
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Engles,
Ferriby, D.
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Pittion Vouyouvitch, S.
Lacour, J. C.
Pelletier, J.
Feuillet, L.
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Renouil Guy, N.
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Benisty, S.
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Anne, O.
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Lensch, E.
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Heidenreich, F.
Trebst, C.
Pul, R.
Hohlfeld, R.
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Haas, J.
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Meyer, R.
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Poehlau, D.
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Hoffmann, V.
Zettl, U.
Steinhagen, V.
Adler, S.
Steinbrecher E. Rothenfusser K\uf6rber, A. Steinbrecher E. Rothenfusser K\uf6rber
Zellner, R.
Baum, K.
G\ufcnther, A.
Bl\ue4sing, H.
Stoll, G.
Gold, R.
Bayas, A.
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Limmroth, V.
Katsarava, Z.
Kastrup, O.
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Oschmann, P.
Voigt, K.
Burger, C. V.
Abramsky, : O.
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Achiron, A.
Kishner, I.
Stern, Y.
Sarove Pinhas, I.
Dolev, M.
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Pozzili, : C.
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Scontrini, A.
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Buttinelli, C.
Gallo, P.
Ranzato, F.
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Perini, P.
LARONI, ALICE
Marrosu, M.
Cocco P. Marchi, E. Cocco P. Marchi
Spinicci, G.
Massole, S.
Mascia, M.
Floris, G.
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Paolicelli, D.
Bosco Zimatore, G.
Simone, I. L.
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Di Monte, E.
MANCARDI, GIOVANNI LUIGI
Pizzorno, M.
Murialdo, A.
Narciso, E.
Capello, A.
Comi, G.
Martinelli, V.
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Polman, : C. H.
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Cadivid, D.
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Turel, A.
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Elias, S.
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Celesia, G.
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Wolintz, R.
Drasby, E.
Muscat, P.
Belden, J.
Sullivan, R.
Cohen, J.
Stone, L.
Marrie, R. A.
Fox, R.
Hughes, B.
Babikian, P.
Jacoby, M.
Doro, J.
Puricelli, M.
Rossman, H.
Boudoris, W.
Belkin, M.
Pierce, R.
Eggenberger, E.
Birbeck, G.
Martin, J.
Kaufman, D.
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English, J. B.
Stuart, D. S.
Gilbert, R. W.
Kaufman, M.
Putman, S.
Diedrich, A.
Follmer, R.
Pelletier, D.
Waubant, E.
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Genain, C.
Goodin, D.
Guarnaccia, J.
Patwa, H.
Rizo, M.
Kitaj, M.
Blevins, J.
Smith, T.
Mcgee, F.
Honeycutt, W.
Brown, M.
Isa, A.
Nieves Quinones, D.
Krupp, L.
Smiroldo, J.
Zarif, M.
Perkins, C.
Sumner, A.
Fisher, A.
Gutierrez, A.
Jacoby, R.
Svoboda, S.
Dorn, D.
Groeschel, A.
Steingo, B.
Kishner, R.
Cohen, B.
Melen, O.
Simuni, T.
Zee, P.
Cohan, S.
Yerby, M.
Hendin, B.
Levine, T.
Tamm, H.
Travis, L. H.
Freedman, S. M.
Tim, R.
Ferrell, W.
Stefoski, D.
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Topel, J.
Ko, M.
Gelber, D.
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Logan, W.
Carpenter, D.
Temple, L.
Sadiq, S.
Sylvester, A.
Sim, G.
Mihai, C.
Vertino, M.
Jubelt, B.
Mejico, L.
Phillips, J. T.
Martin, A.
Heitzman, D.
Greenfield, C. F.
Riskind, P.
Cabo, A.
Paskavitz, J.
Moonis, M.
Bashir J. Brockington, K. Bashir J. Brockington
Nicholas, A.
Slaughter, R.
Archer S. Harik, R. Archer S. Harik
Haddad, N.
Pippenger, M. A.
Van den Noort, S.
Thai, G.
Olek, M.
Demetriou, M.
Shin, R.
Calabresi, P.
Rus, H.
Bever, C.
Johnson, K.
Sheremata, W.
Delgado, S.
Sherbert, R.
Herndon, R.
Uschmann, H.
Chandler, A.
Markowitz, C.
Jacobs, D.
Balcer, L.
Mitchell, G.
Chakravorty, S.
Heyman, R.
Stauber, Z.
Goodman, A.
Segal, B.
Schwid, S.
Samkoff, L.
Levin, M.
Jacewicz, M.
Menkes, D.
Pulsinelli, W.
Frohman, E.
Racke, M.
Hawker, K.
Ulrich, R.
Panitch, H.
Hamill, R.
Tandon, R.
Dulaney, E.
Simnad, V.
Miller, J.
Wooten, G. F.
Harrison, M.
Bowen, J.
Doherty, M.
Wundes, A.
Garden, G. A.
Distad, J.
Kachuck, N.
Berkovich, R.
Burnett, M.
Sahai, S.
Bandari, D.
Weiner, L.
Storey, J. R.
Beesley, B.
Hart, D.
Moses, H.
Sriram, S.
Fang, J.
O\u2019Duffy, A.
Kita, M.
Taylor, L.
Elliott, M.
Roberts, J.
Jeffery, D.
Maxwell, S.
Lefkowitz, D.
Kumar, S.
Sinclair, M.
Radue, E. W.
de Vera, A.
Bacelar, O.
Kuster, P.
Kappos, L.

January 2007

Objective: To report the relationship between disease activity and health-related quality of life (H...

Design of TRUST, a non-interventional, multicenter, 3-year prospective study investigating an integrated patient management approach in patients with relapsing-remitting multiple sclerosis treated with natalizumab

Ziemssen, Tjalf
Gass, Hans-Joachim
Würfel, Jens
Bayas, Antonios
Tackenberg, Björn
Limmroth, Volker
Linker, Ralf
Mäurer, Mathias
Haas, Judith
Stangel, Martin
Meergans, Matthias
Harlin, Olof
Hartung, Hans-Peter

January 2016

Background: Natalizumab provides rapid and high-efficacy control of multiple sclerosis disease activ...

Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis

van Lierop, Zoë Y. GJ
Wieske, Luuk
Koel-Simmelink, Marleen J. A.
Chatterjee, Madhurima
Dekker, Iris
Leurs, Cyra E.
Willemse, Eline A. J.
Moraal, Bastiaan
Barkhof, Frederik
Eftimov, Filip
Uitdehaag, Bernhard M. J.
Killestein, Joep
Teunissen, Charlotte E.

January 2021

Background: Natalizumab treatment provides a model for non-inflammation-induced disease progression ...

Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis

van Lierop, Zoë Y. GJ
Noteboom, Samantha
Steenwijk, Martijn D.
van Dam, Maureen
Toorop, Alyssa A.
van Kempen, Zoé L. E.
Moraal, Bastiaan
Barkhof, Frederik
Uitdehaag, Bernard M. J.
Schoonheim, Menno M.
Teunissen, Charlotte E.
Killestein, Joep

December 2022

Background: Despite highly effective treatment strategies for patients with relapsing-remitting mult...

Serum Neurofilament Light Association With Progression in Natalizumab-Treated Patients With Relapsing-Remitting Multiple Sclerosis

Bridel, C
Leurs, CE
van Lierop, ZYGJ
van Kempen, ZLE
Dekker, I
Twaalfhoven, HAM
Moraal, B
Barkhof, F
Uitdehaag, BMJ
Killestein, J
Teunissen, CE

November 2021

OBJECTIVE: The objective of this study was to investigate the potential of serum neurofilament light...

Inflammatory Activity on Natalizumab Predicts Short-term but not Long-term Disability in Multiple Sclerosis

Raffel, J
Gafson, AR
Dahdaleh, S
Malik, O
Jones, B
Nicholas, R

January 2017

BACKGROUND: In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, ne...

Long-term disease activity and disability progression in relapsing-remitting multiple sclerosis patients on natalizumab

Dekker, I
Leurs, C E
Hagens, M H J
van Kempen, Z L E
Kleerekooper, I
Lissenberg-Witte, B I
Barkhof, F
Uitdehaag, B M J
Balk, L J
Wattjes, M P
Killestein, J

August 2019

BACKGROUND: Natalizumab is an effective treatment for relapsing-remitting multiple sclerosis (RRMS)....

Wearing-off at the end of natalizumab dosing interval and risk of MS disease activity: A prospective 1-year follow-up study

Bringeland, Gerd Haga
Myhr, Kjell-Morten
Vedeler, Christian A.
Gavasso, Sonia

January 2020

Natalizumab effectively prevents disease activity in relapsing-remitting multiple sclerosis by bindi...

Serum glial fibrillary acidic protein in natalizumab-treated relapsing-remitting multiple sclerosis: An alternative to neurofilament light

Wessels, Mark Hj
Van Lierop, Zoë YGJ
Noteboom, Samantha
Strijbis, Eva MM
Heijst, Johannes A
Van Kempen, Zoé LE
Moraal, Bastiaan
Barkhof, Frederik
Uitdehaag, Bernard MJ
Schoonheim, Menno M
Killestein, Joep
Teunissen, Charlotte E

September 2023

BACKGROUND: There is a need in Relapsing-Remitting Multiple Sclerosis (RRMS) treatment for biomarker...

Assessing disease activity in multiple sclerosis: biomarkers and clinical measures

Raffel, Joel Benjamin

May 2020

Background: Multiple sclerosis (MS) is the commonest cause of non-traumatic neurological disability ...

Brain-derived neurotrophic factor levels under chronic natalizumab treatment in multiple sclerosis. A preliminary report

Văcăraş, Vitalie
Major, Zoltán Zsigmond
Buzoianu, Anca Dana

January 1970

Aim of the study Our main purpose was to investigate if the chronic treatment with the disease-modif...

Inflammatory Activity on Natalizumab Predicts Short-Term but Not Long-Term Disability in Multiple Sclerosis

Raffel Joel
Gafson Arie R.
Dahdaleh Samer
Malik Omar
Jones Brynmor
Nicholas Richard

January 2017

In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesion...

Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy

Nováková Nyrén, Lenka

March 2018

The pathophysiology of multiple sclerosis (MS) is complex with the presence of inflammation and neur...

The effect of natalizumab on disability score and relapse rate of multiple sclerosis patients: a prospective cohort study

Mehrdokht Mazdeh
Shno Hosseini
Mohammad Taheri
Soudeh Ghafouri-Fard

November 2018

Abstract Multiple sclerosis (MS) is a progressive immune-related disorder of the central nervous sys...

Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up

Maxi Kaufmann
Rocco Haase
Undine Proschmann
Tjalf Ziemssen
Katja Akgün

December 2018

Natalizumab inhibits the transmigration of immune cells across the blood-brain barrier thus inhibiti...

Rudick, R. A.
Miller, D.
Hass, S.
Hutchinson, M
Calabresi, P. A.
Confavreux, C.
Galetta, S. L.
Giovannoni, G.
Havrdova, E.
Kappos, L.
Lublin, F. D.
Miller, D. H.
O'Connor, P. W.
Phillips, J. T.
Polman, C. H.
Radue, Ew
Stuart, W. H.
Wajgt, A.
Weinstock Guttman, B.
Wynn, D. R.
Lynn, F.
Panzara, M. A.
Affirm,
SENTINEL Investigators including: R., Macdonell
Hughes, A.
Taylor, I.
Lee, Y. C.
Ma, H.
King, J.
Kilpatrick, T.
Butzkueven, H.
Marriott, M.
Pollard, J.
Spring, P.
Spies, J.
Barnett, M.
Dehaene, I.
Vanopdenbosch, L.
D\u2019Hooghe, M.
Van Zandijcke, M.
Derijck, O.
Seeldrayers, P.
Jacquy, J.
Piette, T.
De Cock, C.
Medaer, R.
Soors, P.
Vanroose, E.
Vanderhoven, L.
D\u2019Hooghe, M.
Nagels, G.
Dubois, B.
Deville, M. C.
D\u2019Haene, R.
Jacques, F.
Hall\ue9, D.
Gagnon, S.
Likavcan, E.
Murray, T. J.
Bhan, V.
Mackelvey, R.
Maxner, C. E.
Christie, S.
Giaccone, R.
Guzman, D. A.
Melanson, M.
Esfahani, F.
Gomori, A. J.
Nagaria, M. H.
Grand\u2019Maison, F.
Berger, L.
Nasreddine, Z.
Duplessis, M.
Brunet, D.
Melanson, M.
Jackson, A.
Pari, G.
O\u2019Connor, P.
Gray, T.
Hohol, M.
Marchetti, P.
Lee, L.
Murray, B.
Sahlas, J.
Perry, J.
Devonshire, V.
Hooge, J.
Hashimoto, S.
Oger, J.
Smyth, P.
Rice, G.
Kremenchutzky, M.
Stourac, P.
Kadanka, Z.
Benesova, Y.
Niedermayerova, I.
Meluzinova, E.
Marusic, P.
M,
Bojar,
Zarubova, K.
Houzvickov\ue1, E.
Pikov\ue1, J.
Talab, R.
Faculty, Hospital Olomouc
Olomouc, B. Muchova
Urb\ue1nek, K
Kettnerova, Z.
Mares, J.
Otruba, P.
Zapletalov\ue1, O.
Hradilek, P.
Ddolezil, D. Dolezil
Woznicova, I.
H\uf6fer, R.
Ambler J. Fiedler, Z. Ambler J. Fiedler
Sucha, J.
Matousek, V.
Rektor, I.
Dufek, M.
Mikulik, R.
Mastik, J.
Tyrlikova, I.
General, Teaching Hospital
Prague, E. Havrdov\ue1
Horakova, D.
Kalistov\ue1, H.
T\ufdblov\ue1, M.
Ehler, E.
Novotn\ue1, A.
Geier, P.
Soelberg Sorensen, P.
Ravnborg, M.
Petersen, B.
Blinkenberg, M.
F\ue4rkkil\ue4, M.
Harno, H.
Kallela, M.
H\ue4pp\uf6l\ue4, O.
Elovaara, I.
Kuusisto, H.
Ukkonen, M.
Peltola, J.
Palmio, J.
Pelletier, J.
Feuillet, L.
Suchet, L.
Dalecky, A.
Tammam, D.
Edan, G.
Le Page, E.
M\ue9rienne, M.
Yaouanq, J.
Clanet, M.
Mekies, C.
Azais Vuillemin, C.
Senard, A.
Lau, G.
Steinmetz, G.
Warter V. Wolff, J. Warter V. Wolff
Fleury, M.
Tranchant, C.
Stark, E.
Buckpesch Heberer, U.
Henn, K. H.
Skoberne, T.
Schimrigk, S.
Hellwig, K.
Brune, N.
Weiller, C.
Gbadamosi, J.
R\uf6ther, J.
Heesen, C.
Buhmann, C.
Karageorgiou, C.
Korakaki, D.
Giannoulis, D. r.
Tsiara, S.
Thomaides, T.
Thomopoulos, I.
Papageorgiou, H.
Armakola, F.
Komoly, S.
R\uf3zsa, C.
Matolcsi, J.
Szab\uf3, G. y.
Moln\ue1r, B.
Lovas, G.
Dioszeghy, P.
Szulics, P.
Magyar, Z.
Incze, J.
Farkas, J.
Clemens, B.
K\ue1nya, J.
Valicsk\uf3, Z. s.
Bense, E.
Nagy, Z. s.
Ger\ue9by, G.
Per\ue9nyi, J.
Simon, Z. s.
Szapper, M.
Gedeon, L.
Csanyi, A.
Rum, G.
Lip\uf3th, S.
Szegedi, A.
J\ue1vor, L.
Nagy, I.
Ad\ue1m, I.
Szirmai, I.
Sim\uf3, M.
Ertsey, C.
I,
Amrein,
Kamondi, A.
Harcos, P.
Dobos, E.
Szab\uf3, B.
Balas, V.
Guseo, A.
Fodor, E.
J\uf3fej\ufc, E.
Eizler, K.
Csiba, L.
Cs\ue9p\ue1ny, T.
Pallagi, E.
Bereczki, D.
Jakab, G.
Juh\ue1sz, M.
Bszab\uf3, B. Szab\uf3 I. Mayer
Katona, G.
Hutchinson, M.
O\u2019Dwyer, J.
O\u2019Rourke, K.
Sanders, E. A. C. M.
Rijk van Andel, J. F.
Bomhof, M. A. M.
van Erven, P.
Hintzen I. Hoppenbrouwers, R. Q. Hintzen I. Hoppenbrouwers
Neuteboom, R. F.
Zemel, D.
van Doorn, P. A.
Jacobs, B. C.
Munster, E. T. h. L. Van
ter Bruggen, J. P.
Bernsen, R.
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de Smet, E. A. A.
Tacken, H. F. H.
Polman, C.
Zwemmer, J.
Nielsen, J.
Kalkers, N.
Kragt, J.
Jasperse, B.
Willoughby, E.
Anderson, N. E.
Barber, A.
Anderson, T.
Parkin, P. J.
Fink, J.
Avery, S.
Mason, D.
Kwiecinski, H.
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Kaminska, A.
Podlecka, A.
Nojszewska, M.
Czlonkowska, A.
Zaborski, J.
Wicha, W.
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Darda Ledzion, L.
Selmaj, K.
Mochecka Thoelke, A.
Pentela Nowicka, J.
Walczak, A.
Stasiolek, M.
Stelmasiak, Z.
Bartosik Psujek, H.
Mitosek Szewczyk, K.
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Strzyzewska Lubos, L.
Lubos, L.
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Niezgodzinska Maciejek, A.
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Zimnoch, R.
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Gryz Kurek, E.
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Brundin, L.
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Naegelin, Y.
Eraksoy, M.
Bebek, N.
Akman Demir, G.
Topcuoglu, B.
Kurtuncu, M.
Istanbul, University
Istanbul:, A. Siva
Saip, S.
Altintas, A.
Kiyat, A.
Sharief, M.
Kasti, M.
Giovannoni, G.
Lim, E. T.
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Decoo, : D
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Shorsh, K.
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Soelberg S\uf8rensen, P.
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Petersen, B.
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Bech, E.
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Kirkegaard, M.
Eralinna, : J.
Ruutiainen, J.
Soilu H\ue4nninen, M.
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Engles,
Ferriby, D.
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Steinbrecher E. Rothenfusser K\uf6rber, A. Steinbrecher E. Rothenfusser K\uf6rber
Zellner, R.
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LARONI, ALICE
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Cocco P. Marchi, E. Cocco P. Marchi
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Floris, G.
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Paolicelli, D.
Bosco Zimatore, G.
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Di Monte, E.
MANCARDI, GIOVANNI LUIGI
Pizzorno, M.
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Sriram, S.
Fang, J.
O\u2019Duffy, A.
Kita, M.
Taylor, L.
Elliott, M.
Roberts, J.
Jeffery, D.
Maxwell, S.
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Kuster, P.
Kappos, L.

January 2007

Objective: To report the relationship between disease activity and health-related quality of life (H...

Design of TRUST, a non-interventional, multicenter, 3-year prospective study investigating an integrated patient management approach in patients with relapsing-remitting multiple sclerosis treated with natalizumab

Ziemssen, Tjalf
Gass, Hans-Joachim
Würfel, Jens
Bayas, Antonios
Tackenberg, Björn
Limmroth, Volker
Linker, Ralf
Mäurer, Mathias
Haas, Judith
Stangel, Martin
Meergans, Matthias
Harlin, Olof
Hartung, Hans-Peter

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Background: Natalizumab provides rapid and high-efficacy control of multiple sclerosis disease activ...

Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis.

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