Abstract: SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are interconnected to each other to form a distinct module. In this structure the chromodomain makes interdomain interactions and has lost its canonical function to bind to methylated lysines. The structure provides new insights into the missense mutations that target this module in cancer. This study also reveals two adjacent, highly-conserved pockets in a cleft between the domains that form a potential binding site, which can be targeted w...
In eukaryotic systems, the genetic material of the cell –DNA– is packed into a protein-dense structu...
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-t...
Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated ...
SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and at...
International audienceTo activate or repress specific genes, chromatin is constantly modified by chr...
In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regula...
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodelin...
Over the past 4 years, nearly 100 exome sequencing studies have revealed the high frequency of mutat...
Summary: The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberr...
BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that recruit the comple...
Genes encoding subunits of the SWI/SNF chromatin remodeling complex are frequently mutated in a wide...
Recent studies have established that two core members of the SWI/SNF chromatin remodeling complex, B...
Poster Presentation: no. P68Mammalian BAF complexes are a subfamily of SWI/SNF ATP-dependent chromat...
Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequent...
BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that recruit the comple...
In eukaryotic systems, the genetic material of the cell –DNA– is packed into a protein-dense structu...
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-t...
Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated ...
SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and at...
International audienceTo activate or repress specific genes, chromatin is constantly modified by chr...
In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regula...
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodelin...
Over the past 4 years, nearly 100 exome sequencing studies have revealed the high frequency of mutat...
Summary: The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberr...
BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that recruit the comple...
Genes encoding subunits of the SWI/SNF chromatin remodeling complex are frequently mutated in a wide...
Recent studies have established that two core members of the SWI/SNF chromatin remodeling complex, B...
Poster Presentation: no. P68Mammalian BAF complexes are a subfamily of SWI/SNF ATP-dependent chromat...
Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequent...
BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that recruit the comple...
In eukaryotic systems, the genetic material of the cell –DNA– is packed into a protein-dense structu...
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-t...
Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated ...