A longitudinal study of systemic inflammation and recovery of lean body mass among malnourished HIV-infected adults starting antiretroviral therapy in Tanzania and Zambia.

PrayGod, G
Blevins, M
Woodd, S
Rehman, AM
Jeremiah, K
Friis, H
Kelly, P
Changalucha, J
Heimburger, DC
Filteau, S
Koethe, JR

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Publication date

January 2016

DOI

10.1038/ejcn.2016.1

Publisher

Springer Science and Business Media LLC

ISSN

0954-3007

Citation count (estimate)

Abstract

BACKGROUND/OBJECTIVES: The effects of inflammation on nutritional rehabilitation after starting antiretroviral therapy (ART) are not well understood. We assessed the relationship between inflammation and body composition among patients enrolled in the Nutritional Support for African Adults Starting Antiretroviral therapy (NUSTART) trial in Tanzania and Zambia from 2011 to 2013. SUBJECTS/METHODS: HIV-infected, ART-eligible adults with body mass index (BMI) of <18.5 kg/m(2) enrolled in the NUSTART trial were eligible for this study. Anthropometric and body composition data were collected at recruitment and 6 and 12 weeks post ART and C-reactive protein (CRP) was measured at recruitment and 6 weeks. The relationships between CRP and body compo...