Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been revealed in vertebrates and Drosophila. Some of these peptides have essential and conserved cellular functions. In Drosophila, we have predicted a particular smORF class encoding ~80 aa hydrophobic peptides, which may function in membranes and cell organelles. Here, we characterise hemotin, a gene encoding an 88aa transmembrane smORF peptide localised to early endosomes in Drosophila macrophages. hemotin regulates endosomal maturation during phagocytosis by repressing the cooperation of 14-3-3ζ with specific phosphatidylinositol (PI) enzymes. hemotin mutants accumulate undigested phagocytic material inside enlarged endo-lysosomes and as a result, h...
Antimicrobial peptides (AMPs) are key players in innate defence against infection in plants and anim...
Insects are useful models for the study of innate immune reactions and development. The distinction ...
SummaryThe removal of apoptotic cells by phagocytic neighbors is essential for metazoan development ...
Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been reveal...
The humoral response to fungal and Gram-positive infections is regulated by the serpin-family inhibi...
In Drosophila, anti-microbial peptides are activated and secreted in response to microbial challenge...
We describe the isolation and initial characterization of hemomucin, a novel Drosophila surface muci...
SummaryPhagocytosis is a complex, evolutionarily conserved process that plays a central role in host...
We have identified a previously undescribed transmembrane protein, Hemese, from Drosophila melanogas...
<div><p>Apart from their role in cellular immunity via phagocytosis and encapsulation, <i>Drosophila...
Apart from their role in cellular immunity via phagocytosis and encapsulation, Drosophila hemocytes ...
Clotting is critical in limiting hemolymph loss and initiating wound healing in insects as in verteb...
AbstractClotting is critical in limiting hemolymph loss and initiating wound healing in insects as i...
AbstractBackground: The inducible production of antimicrobial peptides is a major immune response in...
TO identify novel proteins required for receptor-mediated endocytosis, we have developed an RNAi-bas...
Antimicrobial peptides (AMPs) are key players in innate defence against infection in plants and anim...
Insects are useful models for the study of innate immune reactions and development. The distinction ...
SummaryThe removal of apoptotic cells by phagocytic neighbors is essential for metazoan development ...
Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been reveal...
The humoral response to fungal and Gram-positive infections is regulated by the serpin-family inhibi...
In Drosophila, anti-microbial peptides are activated and secreted in response to microbial challenge...
We describe the isolation and initial characterization of hemomucin, a novel Drosophila surface muci...
SummaryPhagocytosis is a complex, evolutionarily conserved process that plays a central role in host...
We have identified a previously undescribed transmembrane protein, Hemese, from Drosophila melanogas...
<div><p>Apart from their role in cellular immunity via phagocytosis and encapsulation, <i>Drosophila...
Apart from their role in cellular immunity via phagocytosis and encapsulation, Drosophila hemocytes ...
Clotting is critical in limiting hemolymph loss and initiating wound healing in insects as in verteb...
AbstractClotting is critical in limiting hemolymph loss and initiating wound healing in insects as i...
AbstractBackground: The inducible production of antimicrobial peptides is a major immune response in...
TO identify novel proteins required for receptor-mediated endocytosis, we have developed an RNAi-bas...
Antimicrobial peptides (AMPs) are key players in innate defence against infection in plants and anim...
Insects are useful models for the study of innate immune reactions and development. The distinction ...
SummaryThe removal of apoptotic cells by phagocytic neighbors is essential for metazoan development ...