We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR- and Raman-active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The d...
Platinum(II) complexes containing the strong pi-acceptor N,N-chelating ligand phenylazopyridine (Ph-...
Platinum(IV) complexes are extensively studied for their activity against cancer cells as potential ...
A computational and vibrational spectroscopic study of the aqua complexes obtained by hydrolysis of ...
We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate,...
The photodecomposition mechanism of trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1, py=pyridine), an antic...
The Pt(IV) complex c,c,t-[Pt(NH3)2Cl2(OH)2] is an important intermediate in the synthesis of Pt(IV) ...
The Pt(IV) complex c,c,t-[Pt(NH[subscript 3])[subscript 2]Cl[subscript 2](OH)[subscript 2]] is an im...
A computational and vibrational spectroscopic study of the aqua complexes obtained by hydrolysis of ...
This study reports the optimized structures and lowest-energy conformations/stereochemistry of five ...
This study reports the optimized structures and lowest-energy conformations/stereochemistry of five ...
International audienceCisplatin (cis-diamminedichloroplatinum(II) is the first platinum-based antitu...
Platinum(II) complexes are currently the most widely used drugs in cancer chemotherapy. One strategy...
Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from p...
Platinum(II) complexes containing the strong π-acceptor N,N-chelating ligand phenylazopyridine (Ph-a...
Platinum(IV) complexes are extensively studied for their activity against cancer cells as potential ...
Platinum(II) complexes containing the strong pi-acceptor N,N-chelating ligand phenylazopyridine (Ph-...
Platinum(IV) complexes are extensively studied for their activity against cancer cells as potential ...
A computational and vibrational spectroscopic study of the aqua complexes obtained by hydrolysis of ...
We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate,...
The photodecomposition mechanism of trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1, py=pyridine), an antic...
The Pt(IV) complex c,c,t-[Pt(NH3)2Cl2(OH)2] is an important intermediate in the synthesis of Pt(IV) ...
The Pt(IV) complex c,c,t-[Pt(NH[subscript 3])[subscript 2]Cl[subscript 2](OH)[subscript 2]] is an im...
A computational and vibrational spectroscopic study of the aqua complexes obtained by hydrolysis of ...
This study reports the optimized structures and lowest-energy conformations/stereochemistry of five ...
This study reports the optimized structures and lowest-energy conformations/stereochemistry of five ...
International audienceCisplatin (cis-diamminedichloroplatinum(II) is the first platinum-based antitu...
Platinum(II) complexes are currently the most widely used drugs in cancer chemotherapy. One strategy...
Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from p...
Platinum(II) complexes containing the strong π-acceptor N,N-chelating ligand phenylazopyridine (Ph-a...
Platinum(IV) complexes are extensively studied for their activity against cancer cells as potential ...
Platinum(II) complexes containing the strong pi-acceptor N,N-chelating ligand phenylazopyridine (Ph-...
Platinum(IV) complexes are extensively studied for their activity against cancer cells as potential ...
A computational and vibrational spectroscopic study of the aqua complexes obtained by hydrolysis of ...