Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium
- Milne, R.L.
- Burwinkel, B.
- Michailidou, K.
- Arias-Perez, J-I.
- Pilar Zamora, M.
- Menendez-Rodriguez, P.
- Hardisson, D.
- Mendiola, M.
- Gonzalez-Neira, A.
- Pita, G.
- Rosario Alonso, M.
- Dennis, J.
- Wang, Q.
- Bolla, M.K.
- Swerdlow, A.
- Ashworth, A.
- Orr, N.
- Schoemaker, M.
- Ko, Y-D.
- Brauch, H.
- Hamann, U.
- Andrulis, I.L.
- Knight, J.A.
- Glendon, G.
- Tchatchou, S.
- Matsuo, K.
- Ito, H.
- Iwata, H.
- Tajima, K.
- Li, J.
- Brand, J.S.
- Brenner, H.
- Dieffenbach, A.K.
- Arndt, V.
- Stegmaier, C.
- Lambrechts, D.
- Peuteman, G.
- Christiaens, M-R.
- Smeets, A.
- Jakubowska, A.
- Lubinski, J.
- Jaworska-Bieniek, K.
- Durda, K.
- Hartman, M.
- Hui, M.
- Lim, W.Y.
- Chan, C.W.
- Marme, F.
- Yang, R.
- Bugert, P.
- Lindblom, A.
- Margolin, S.
- Garcia-Closas, M.
- Chanock, S.J.
- Lissowska, J.
- Figueroa, J.D.
- Bojesen, S.E.
- Nordestgaard, B.G.
- Flyger, H.
- Hooning, M.J.
- Kriege, M.
- van den Ouweland, A.M.W.
- Koppert, L.B.
- Fletcher, O.
- Johnson, N.
- dos-Santos-Silva, I.
- Peto, J.
- Zheng, W.
- Deming-Halverson, S.
- Shrubsole, MJ.
- Long, J.
- Chang-Claude, J.
- Rudolph, A.
- Seibold, P.
- Flesch-Janys, D.
- Winqvist, R.
- Pylkas, K.
- Jukkola-Vuorinen, A.
- Grip, M.
- Cox, A.
- Cross, S.S.
- Reed, M.W.R.
- Schmidt, M.K.
- Broeks, A.
- Cornelissen, S.
- Braaf, L.
- Kang, D.
- Choi, J-Y.
- Park, S.K.
- Noh, D-Y.
- Simard, J.
- Dumont, M.
- Goldberg, M.S.
- Labreche, F.
- Fasching, P.A.
- Hein, A.
- Ekici, A.B.
- Beckmann, M.W.
- Radice, P.
- Peterlongo, P.
- Azzollini, J.
- Barile, M.
- Sawyer, E.
- Tomlinson, I.
- Kerin, M.
- Miller, N.
- Hopper, J.L.
- Schmidt, D.F.
- Makalic, E.
- Southey, M.C.
- Teo, S.H.
- Yip, C.H.
- Sivanandan, K.
- Tay, W-T.
- Shen, C-Y.
- Hsiung, C-N.
- Yu, J-C.
- Hou, M-F.
- Guenel, P.
- Truong, T.
- Sanchez, M.
- Mulot, C.
- Blot, W.
- Cai, Q.
- Nevanlinna, H.
- Muranen, T.A.
- Aittomaki, K.
- Blomqvist, C.
- Wu, A.H.
- Tseng, C-C.
- Van den Berg, D.
- Stram, D.O.
- Bogdanova, N.
- Doerk, T.
- Muir, K.
- Lophatananon, A.
- Stewart-Brown, S.
- Siriwanarangsan, P.
- Mannermaa, A.
- Kataja, V.
- Kosma, V-M.
- Hartikainen, J.M.
- Shu, X-O.
- Lu, W.
- Gao, Y-T.
- Zhang, B.
- Couch, F.J.
- Toland, A.E.
- Yannoukakos, D.
- Sangrajrang, S.
- McKay, J.
- Wang, X.
- Olson, J.E.
- Vachon, C.
- Purrington, K.
- Severi, G.
- Baglietto, L.
- Haiman, C.A.
- Henderson, B.E.
- Schumacher, F.
- Le Marchand, L.
- Devilee, P.
- Tollenaar, R.A.E.M.
- Seynaeve, C.
- Czene, K.
- Eriksson, M.
- Humphreys, K.
- Darabi, H.
- Ahmed, S.
- Shah, M.
- Pharoah, P.D.P.
- Hall, P.
- Giles, G.G.
- Benitez, J.
- Dunning, A.M.
- Chenevix-Trench, G.
- Easton, D.F.
- Network, GENICA
- Investigators, K
- Grp, AOCS
- TNBCC
DOIAbstract
Candidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most studies have been underpowered to detect associations of a realistic magnitude. We assessed 41 common non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence of association with breast cancer risk had been previously reported. Case-control data were combined from 38 studies of white European women (46 450 cases and 42 600 controls) and analyzed using unconditional logistic regression. Strong evidence of association was observed for three nsSNPs: ATXN7-K264R at 3p21 [rs1053338, per allele OR 5 1.07, 95% confidence interval (CI) 5 1.04–1.10, P 5 2.9 3 1026 ], AKAP9-M463I at ...
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