Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
- Shi, J.
- Zhang, Y.
- Zheng, W.
- Michailidou, K.
- Ghoussaini, M.
- Bolla, M.K.
- Wang, Q.
- Dennis, J.
- Lush, M.
- Milne, R.L.
- Shu, X-O.
- Beesley, J.
- Kar, S.
- Andrulis, I.L.
- Anton-Culver, H.
- Arndt, V.
- Beckmann, M.W.
- Zhao, Z.
- Guo, X.
- Benitez, J.
- Beeghly-Fadiel, A.
- Blot, W.
- Bogdanova, N.V.
- Bojesen, S.E.
- Brauch, H.
- Brenner, H.
- Brinton, L.
- Broeks, A.
- Brüning, T.
- Burwinkel, B.
- Cai, H.
- Canisius, S.
- Chang-Claude, J.
- Choi, J-Y.
- Couch, F.J.
- Cox, A.
- Cross, S.S.
- Czene, K.
- Darabi, H.
- Devilee, P.
- Droit, A.
- Dork, T.
- Fasching, P.A.
- Fletcher, O.
- Flyger, H.
- Fostira, F.
- Gaborieau, V.
- García-Closas, M.
- Giles, G.G.
- Grip, M.
- Guenel, P.
- Haiman, C.A.
- Hamann, U.
- Hartman, M.
- Miao, H.
- Hollestelle, A.
- Hopper, J.L.
- Hsiung, C-N.
- Ito, H.
- Jakubowska, A.
- Johnson, N.
- Torres, D.
- Kabisch, M.
- Kang, D.
- Khan, S.
- Knight, J.A.
- Kosma, V-M.
- Lambrechts, D.
- Li, J.
- Lindblom, A.
- Lophatananon, A.
- Lubinski, J.
- Mannermaa, A.
- Manoukian, S.
- Le Marchand, L.
- Margolin, S.
- Marme, F.
- Matsuo, K.
- McLean, C.
- Meindl, A.
- Muir, K.
- Neuhausen, S.L.
- Nevanlinna, H.
- Nord, S.
- Børresen-Dale, A-L.
- Olson, J.E.
- Orr, N.
- van den Ouweland, A.M.W
- Peterlongo, P.
- Putti, T.C.
- Rudolph, A.
- Sangrajrang, S.
- Sawyer, E.J.
- Schmidt, M.K.
- Schmutzler, R.K.
- Shen, C-Y.
- Hou, M-F.
- Shrubsole, M.J.
- Southey, M.C.
- Swerdlow, A.
- Teo, S.H.
- Thienpont, B.
- Toland, A.E.
- Tollenaar, R.A.E.M.
- Tomlinson, I.
- Truong, T.
- Tseng, C-C.
- Wen, W.
- Winqvist, R.
- Wu, A.H.
- Yip, C.H.
- Zamora, P.M.
- Zheng, Y.
- Floris, G.
- Cheng, C-Y.
- Hooning, M.J.
- Martens, J.W.M.
- Seynaeve, C.
- Kristensen, V.N.
- Hall, P.
- Pharoah, P.D.P.
- Simard, J.
- Chenevix-Trench, G.
- Dunning, A.M.
- Antoniou, A.C.
- Easton, D.F.
- Cai, Q.
- Long, J.
DOIAbstract
Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. We conducted a fine-mapping study across 2.06 Mb (chr8:127,561,724 -129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium. We found three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional P = 5.8 × 10-6), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional P = 1.1 × 10-6), and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional P = 1.1 × 10-4). Integrative analys...
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