The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape. This model associates the global properties of the fitness landscape with the algebraic properties of a Markov chain transition matrix and allows us to derive general results on the non-commutativity and irreversibility of natural selection as well as antibiotic cycling strategies. Using this formalism, we analyze 15 empirical fitness landscapes of E. coli under selection by different β-lactam antibiotics and demonstrate that the emergence of res...
The spread of antibiotic resistance is a global challenge that is fueled by evolution and ecological...
Antibiotic resistance can emerge spontaneously through genomic mutation and render treatmen...
The emergence and dissemination of antibiotic resistance among microorganisms poses a dramatic threa...
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments pr...
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments pr...
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments pr...
<div><p>The development of reliable methods for restoring susceptibility after antibiotic resistance...
The development of reliable methods for restoring susceptibility after antibiotic resistance arises ...
Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an an...
Evolutionary adaptation is a major source of antibiotic resistance in bacterial pathogens. Evolution...
Evolutionary adaptation is a major source of antibiotic resistance in bacterial pathogens. Evolution...
Antibiotic resistance, one of the most pressing challenges facing public health today, arises when a...
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population...
Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery o...
<div><p>The evolution of antibiotic resistance among bacteria threatens our continued ability to tre...
The spread of antibiotic resistance is a global challenge that is fueled by evolution and ecological...
Antibiotic resistance can emerge spontaneously through genomic mutation and render treatmen...
The emergence and dissemination of antibiotic resistance among microorganisms poses a dramatic threa...
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments pr...
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments pr...
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments pr...
<div><p>The development of reliable methods for restoring susceptibility after antibiotic resistance...
The development of reliable methods for restoring susceptibility after antibiotic resistance arises ...
Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an an...
Evolutionary adaptation is a major source of antibiotic resistance in bacterial pathogens. Evolution...
Evolutionary adaptation is a major source of antibiotic resistance in bacterial pathogens. Evolution...
Antibiotic resistance, one of the most pressing challenges facing public health today, arises when a...
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population...
Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery o...
<div><p>The evolution of antibiotic resistance among bacteria threatens our continued ability to tre...
The spread of antibiotic resistance is a global challenge that is fueled by evolution and ecological...
Antibiotic resistance can emerge spontaneously through genomic mutation and render treatmen...
The emergence and dissemination of antibiotic resistance among microorganisms poses a dramatic threa...