Considering cells as biofactories, we aimed to optimize its internal processes by using the same engineering principles that large industries are implementing nowadays: lean manufacturing. We have applied reverse engineering computational methods to transcriptomic, metabolomic and phenomic data obtained from a collection of tomato recombinant inbreed lines to formulate a kinetic and constraint-based model that efficiently describes the cellular metabolism from expression of a minimal core of genes. Based on predicted metabolic profiles, a close association with agronomic and organoleptic properties of the ripe fruit was revealed with high statistical confidence. Inspired in a synthetic biology approach, the model was used for exploring the ...
<p>Heuristic exploration (A) and statistical significance (B) of the landscape of multiple desired a...
Tomato (Solanum lycopersicum L.) is a major horticultural crop and a model species among eudicots, e...
International audienceModelling of metabolic networks is a powerful tool to analyse the behaviour of...
Considering cells as biofactories, we aimed to optimize its internal processes by using the same eng...
The capacity to assimilate carbon and nitrogen, to transport the resultant sugars and amino acids to...
Abstract Background The environment has a profound influence on the organoleptic quality of tomato (...
Tomato is currently the model species for fleshy fruit development and for Solanaceae species. The r...
International audienceAbstract Predicting and understanding plant responses to perturbations require...
BackgroundThe environment has a profound influence on the organoleptic quality of tomato (Solanum ly...
Abstract Humans heavily rely on dozens of domesticated plant species that have been further improv...
Tomatoes are the fourth most valuable commodity in agriculture after rice, wheat and soybeans global...
Tomato has quickly become a favoured species for metabolomics research. Tomato fills a niche that ca...
The gaseous plant hormone ethylene is involved in many physiological processes including climacteric...
Integrative systems biology proposes new approaches to decipher the variation of phenotypic traits. ...
Tomato (Solanum lycopersicum L.) has been studied extensively due to its high economic value in the ...
<p>Heuristic exploration (A) and statistical significance (B) of the landscape of multiple desired a...
Tomato (Solanum lycopersicum L.) is a major horticultural crop and a model species among eudicots, e...
International audienceModelling of metabolic networks is a powerful tool to analyse the behaviour of...
Considering cells as biofactories, we aimed to optimize its internal processes by using the same eng...
The capacity to assimilate carbon and nitrogen, to transport the resultant sugars and amino acids to...
Abstract Background The environment has a profound influence on the organoleptic quality of tomato (...
Tomato is currently the model species for fleshy fruit development and for Solanaceae species. The r...
International audienceAbstract Predicting and understanding plant responses to perturbations require...
BackgroundThe environment has a profound influence on the organoleptic quality of tomato (Solanum ly...
Abstract Humans heavily rely on dozens of domesticated plant species that have been further improv...
Tomatoes are the fourth most valuable commodity in agriculture after rice, wheat and soybeans global...
Tomato has quickly become a favoured species for metabolomics research. Tomato fills a niche that ca...
The gaseous plant hormone ethylene is involved in many physiological processes including climacteric...
Integrative systems biology proposes new approaches to decipher the variation of phenotypic traits. ...
Tomato (Solanum lycopersicum L.) has been studied extensively due to its high economic value in the ...
<p>Heuristic exploration (A) and statistical significance (B) of the landscape of multiple desired a...
Tomato (Solanum lycopersicum L.) is a major horticultural crop and a model species among eudicots, e...
International audienceModelling of metabolic networks is a powerful tool to analyse the behaviour of...