Interleukin (IL)-6 is a potent pro-inflammatory agent that plays a crucial role in the pathogenesis of systemic inflammatory disease. Targeting this pathway in rheumatoid arthritis (RA) seems an attractive option as IL-6 is important for both joint destruction and systemic manifestations. Currently, tocilizumab, which binds the IL-6 receptor, is licensed for treatment in active, moderate to severe disease in RA and systemic juvenile idiopathic arthritis (JIA). Several other promising IL-6 blocking agents as well as a subcutaneous form of tocilizumab are currently undergoing phase III clinical trials. The aim of this article is to provide an up-to-date analysis of clinical efficacy and tolerability data concerning the use of IL-6 inhibitors....
Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under...
Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic disea...
Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under...
Interleukin (IL)-6 is a potent pro-inflammatory agent that plays a crucial role in the pathogenesis ...
Compounds that target interleukin (IL)−6 pathways include antibodies against the IL-6 receptor or li...
BACKGROUND: Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juven...
IL-6 is involved in the pathogenesis of rheumatoid arthritis via its broad effects on immune and inf...
Suppression of the immunoinflammatory cascade by targeting interleukin 6 (IL-6) mediated effects con...
Interleukin (IL)-6 is a cytokine featuring redundancy and pleiotropic activity. While IL-6, when tra...
AbstractInterleukin (IL)-6 is a cytokine with multiple biological activities. It contributes to host...
Immunopathological aspects of interleukin-6 are analyzed, as well as the clinical use of tocilizumab...
<p><em>The article observes the data on the role of interleukin (IL) 6 in pathogenesis of rheumatoid...
Interleukin-6 (IL-6) is a representative cytokine featuring pleiotropic activity and redundancy. A t...
Aarat M Patel 1,2; Larry W Moreland 1; 1 Division of Rheumatology and Clinical Immunology, Universit...
Aarat M Patel 1,2; Larry W Moreland 1; 1 Division of Rheumatology and Clinical Immunology, Universit...
Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under...
Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic disea...
Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under...
Interleukin (IL)-6 is a potent pro-inflammatory agent that plays a crucial role in the pathogenesis ...
Compounds that target interleukin (IL)−6 pathways include antibodies against the IL-6 receptor or li...
BACKGROUND: Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juven...
IL-6 is involved in the pathogenesis of rheumatoid arthritis via its broad effects on immune and inf...
Suppression of the immunoinflammatory cascade by targeting interleukin 6 (IL-6) mediated effects con...
Interleukin (IL)-6 is a cytokine featuring redundancy and pleiotropic activity. While IL-6, when tra...
AbstractInterleukin (IL)-6 is a cytokine with multiple biological activities. It contributes to host...
Immunopathological aspects of interleukin-6 are analyzed, as well as the clinical use of tocilizumab...
<p><em>The article observes the data on the role of interleukin (IL) 6 in pathogenesis of rheumatoid...
Interleukin-6 (IL-6) is a representative cytokine featuring pleiotropic activity and redundancy. A t...
Aarat M Patel 1,2; Larry W Moreland 1; 1 Division of Rheumatology and Clinical Immunology, Universit...
Aarat M Patel 1,2; Larry W Moreland 1; 1 Division of Rheumatology and Clinical Immunology, Universit...
Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under...
Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic disea...
Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under...