The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. Such manipulations alter expressions of mechanosensitive genes which may anticipate induction of morphological changes in the developing heart. This paper aims to present different approaches for generating clinically relevant disturbed hem...
The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardi...
Genetic evidence has implicated several genes as being critical for heart development. However, the ...
During vertebrate embryogenesis the heart is the first functioning organ and cardiac progenitor cell...
The heart is the first functioning organ in the developing embryo and a detailed understanding of th...
• Direct surgical manipulation of the de-veloping embryo heart is one of several physi-cal and chemi...
Innovative research on the interactions between biomechanical load and cardiovascular (CV) morphogen...
Background: Hemodynamics, forces from the flowing blood in the heart, is a major epigenetic factor f...
In the developing embryo the heart is the first organ to develop and thus supply the rest of the dev...
Heart development is a complex process and begins with the long-range migration of cardiac progenito...
<p>Congenital heart disease (CHD) has the highest incidence and mortality rate of all birth defects ...
Despite the extensive information available on the different genetic, epigenetic, and molecular feat...
Cardiac mo rp hogen esis re p resents a balan ce of myocardial d iff e rentiation, growth an d re m ...
Cardiogenesis is interdependent with blood flow within the embryonic system. Recently, a number of s...
Dissertação de mest., Engenharia Biológica, Faculdade de Engenharia de Recursos Naturais, Universida...
Cardiac valve structure and function are primarily determined during early development. Consequently...
The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardi...
Genetic evidence has implicated several genes as being critical for heart development. However, the ...
During vertebrate embryogenesis the heart is the first functioning organ and cardiac progenitor cell...
The heart is the first functioning organ in the developing embryo and a detailed understanding of th...
• Direct surgical manipulation of the de-veloping embryo heart is one of several physi-cal and chemi...
Innovative research on the interactions between biomechanical load and cardiovascular (CV) morphogen...
Background: Hemodynamics, forces from the flowing blood in the heart, is a major epigenetic factor f...
In the developing embryo the heart is the first organ to develop and thus supply the rest of the dev...
Heart development is a complex process and begins with the long-range migration of cardiac progenito...
<p>Congenital heart disease (CHD) has the highest incidence and mortality rate of all birth defects ...
Despite the extensive information available on the different genetic, epigenetic, and molecular feat...
Cardiac mo rp hogen esis re p resents a balan ce of myocardial d iff e rentiation, growth an d re m ...
Cardiogenesis is interdependent with blood flow within the embryonic system. Recently, a number of s...
Dissertação de mest., Engenharia Biológica, Faculdade de Engenharia de Recursos Naturais, Universida...
Cardiac valve structure and function are primarily determined during early development. Consequently...
The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardi...
Genetic evidence has implicated several genes as being critical for heart development. However, the ...
During vertebrate embryogenesis the heart is the first functioning organ and cardiac progenitor cell...