The Aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular astrocyte endfeet where it is concentrated. We postulated that AQP4 is tethered at this site by binding of the AQP4 C terminus to the PSD95-Discs large-ZO1 (PDZ) domain of syntrophin, a component of the dystrophin protein complex. Chemical cross-linking and coimmunoprecipitations from brain demonstrated AQP4 in association with the complex, including dystrophin, beta-dystroglycan, and syntrophin. AQP4 expression was studied in brain and skeletal muscle of mice lacking alpha-syntrophin (alpha-Syn(-/-)). The total level of AQP4 expression appears normal in brains of alpha-Syn(-/-) mice, but the polarized subcellular localization is reversed. High-resol...
Translational readthrough (TRT) of aquaporin-4 (AQP4) has remarkably expanded the importance of this...
Translational readthrough (TRT) of aquaporin-4 (AQP4) has remarkably expanded the importance of this...
Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes ...
The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocy...
Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)—a water channel that is crit...
Regulation of water homeostasis is a central feature of central nervous system pathophysiology. In t...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
Cerebral water accumulation was studied during induction of brain edema in dystrophin-null transgeni...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
In a recent study, we demonstrated that in the plasma membrane AQP4 is organized into several distin...
Aquaporin-4 (AQP4) is a water channel protein that links the astrocytic endfeet to the blood-brain b...
Dystrophin and the α-dystrobrevins bind directly to the adaptor protein syntrophin to form membrane-...
Altered aquaporin-4 (AQP4) expression has been reported in brain edema, tumors, muscular dystrophy, ...
We report a detailed study of AQP4 expression in the neuromuscular system of mdx mice. Immunocytoche...
Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by...
Translational readthrough (TRT) of aquaporin-4 (AQP4) has remarkably expanded the importance of this...
Translational readthrough (TRT) of aquaporin-4 (AQP4) has remarkably expanded the importance of this...
Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes ...
The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocy...
Perivascular endfeet of astrocytes are enriched with aquaporin-4 (AQP4)—a water channel that is crit...
Regulation of water homeostasis is a central feature of central nervous system pathophysiology. In t...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
Cerebral water accumulation was studied during induction of brain edema in dystrophin-null transgeni...
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the centr...
In a recent study, we demonstrated that in the plasma membrane AQP4 is organized into several distin...
Aquaporin-4 (AQP4) is a water channel protein that links the astrocytic endfeet to the blood-brain b...
Dystrophin and the α-dystrobrevins bind directly to the adaptor protein syntrophin to form membrane-...
Altered aquaporin-4 (AQP4) expression has been reported in brain edema, tumors, muscular dystrophy, ...
We report a detailed study of AQP4 expression in the neuromuscular system of mdx mice. Immunocytoche...
Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by...
Translational readthrough (TRT) of aquaporin-4 (AQP4) has remarkably expanded the importance of this...
Translational readthrough (TRT) of aquaporin-4 (AQP4) has remarkably expanded the importance of this...
Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes ...