Add to ORKGMarfan Syndrome (MFS) is a highly penetrant, autosomal dominant disease of the connective tissues caused by mutations to the Fibrillin-1 (FBN1) gene. MFS associates with excessive activation of the canonical (SMAD) and noncanonical (MAPKs: ERK, p38, JNK) TGFβ signaling cascades. Patients can display symptoms across the ocular, pulmonary, integumentary, skeletal, and, most importantly, cardiovascular systems. The most common cause of morbidity and mortality in MFS patients is aortic root aneurysm with the potential for progression to an aortic dissection. Even within single families harboring identical FBN1 mutations, there can be high variability in disease severity. The purpose of this dissertation work was to identify genetic modifiers of...
Marfan syndrome is an autosomal dominant disease of connective tissue caused by mutations in the fib...
PURPOSE OF REVIEW: Although historically Marfan syndrome (MFS) has always been considered as a condi...
Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of connective tiss...
Marfan syndrome (MFS) is one of several related disorders that is driven by increased TGFβ signaling...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1, a matrix c...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
Marfan Syndrome (MFS) is a rare connective tissue disorder, resulting from mutations in the fibrilli...
International audienceMarfan syndrome (MFS) is a rare autosomal dominant connective tissue disorder ...
ObjectiveMarfan syndrome is a systemic connective tissue disorder caused by mutations in the fibrill...
Aortic aneurysms and dissections are an important cause of morbidity and mortality in the aging popu...
[eng] Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that af...
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which e...
The starting point, in Marfan syndrome (MFS) appears to be the mutation of fi brillin-1 gene whose d...
Marfan syndrome is an autosomal dominant disease of connective tissue caused by mutations in the fib...
PURPOSE OF REVIEW: Although historically Marfan syndrome (MFS) has always been considered as a condi...
Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of connective tiss...
Marfan syndrome (MFS) is one of several related disorders that is driven by increased TGFβ signaling...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1, a matrix c...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
Marfan Syndrome (MFS) is a rare connective tissue disorder, resulting from mutations in the fibrilli...
International audienceMarfan syndrome (MFS) is a rare autosomal dominant connective tissue disorder ...
ObjectiveMarfan syndrome is a systemic connective tissue disorder caused by mutations in the fibrill...
Aortic aneurysms and dissections are an important cause of morbidity and mortality in the aging popu...
[eng] Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that af...
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which e...
The starting point, in Marfan syndrome (MFS) appears to be the mutation of fi brillin-1 gene whose d...
Marfan syndrome is an autosomal dominant disease of connective tissue caused by mutations in the fib...
PURPOSE OF REVIEW: Although historically Marfan syndrome (MFS) has always been considered as a condi...
Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of connective tiss...