Statistical Methods in the Analysis of Randomized Control Trials: Applications to Pre-Exposure Prophylaxis for HIV Prevention and a Community Engagement Intervention in East Baltimore

This work focuses on two examples of randomized control trials- a set of Phase II and Phase III clinical trials evaluating pre-exposure prophylaxis for HIV prevention and a cluster randomized trial assessing a community engagement intervention developed to improve health outcomes in Baltimore. We discuss the unique statistical challenges each trial raises, and we present our application of different methods that address them. We conclude by discussing the commonalities between the different trials, ongoing methodological challenges, and future directions for this work