This thesis presents the progress made in constructing synthetic and functional models of a small subset of iron oxygenases, which are enzymes responsible for the activation of dioxygen (O2) for a myriad of biological functions. The subset of interest is comprised of metalloenzymes containing a mononuclear, non-heme iron(II) center that incorporates sulfur donors in the first coordination sphere, as described in Chapter 1. In particular, the synthetic iron(II) complexes of interest are bound by polydentate N4S(thiolate) ligands to mimic the coordination sphere found in the active sites of cysteine dioxygenase (CDO) and superoxide reductase (SOR). In SOR, the cysteine (Cys) thiolate ligation plays an important role in tuning the electronic p...
Two mononuclear iron(II)–thiolate complexes have been prepared that represent structural models of t...
The design of biomimetic model complexes for the cysteine dioxygenase (CDO) and cysteamine dioxygena...
Nature utilizes nonheme diiron, heme-nonheme diiron, and mononuclear heme active site motifs to cata...
Nonheme iron oxidases and oxygenases are a diverse class of metalloenzymes that activate dioxygen fo...
Thesis (Ph.D.)--University of Washington, 2019Dioxygen activation by non-heme thiolate-ligated Fe-en...
Mononuclear non-heme iron dioxygenases (MNIDs) are a class of enzymes that catalyze a variety of rea...
Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol diox...
A nonheme Fe(II) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O2 a...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
Thesis (Ph.D.)--University of Washington, 2021The addition of steric constraints to thiolate-ligated...
The activation and reduction of dioxygen are the most important process in biological respiration an...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
Two mononuclear iron(II)–thiolate complexes have been prepared that represent structural models of t...
The design of biomimetic model complexes for the cysteine dioxygenase (CDO) and cysteamine dioxygena...
Nature utilizes nonheme diiron, heme-nonheme diiron, and mononuclear heme active site motifs to cata...
Nonheme iron oxidases and oxygenases are a diverse class of metalloenzymes that activate dioxygen fo...
Thesis (Ph.D.)--University of Washington, 2019Dioxygen activation by non-heme thiolate-ligated Fe-en...
Mononuclear non-heme iron dioxygenases (MNIDs) are a class of enzymes that catalyze a variety of rea...
Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol diox...
A nonheme Fe(II) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O2 a...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
Thesis (Ph.D.)--University of Washington, 2021The addition of steric constraints to thiolate-ligated...
The activation and reduction of dioxygen are the most important process in biological respiration an...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
The synthesis of four new FeII(N4S(thiolate)) complexes as models of the thiol dioxygenases are des...
Two mononuclear iron(II)–thiolate complexes have been prepared that represent structural models of t...
The design of biomimetic model complexes for the cysteine dioxygenase (CDO) and cysteamine dioxygena...
Nature utilizes nonheme diiron, heme-nonheme diiron, and mononuclear heme active site motifs to cata...