Keratin 9 (KRT9/Krt9) is a type I intermediate filament protein that is constitutively expressed in the suprabasal layer of the thicker and specialized epidermis of the palmoplantar skin. Mutations at the KRT9/Krt9 locus cause epidermolytic palmoplantar keratoderma (EPPK), a rare autosomal dominant disorder characterized by diffuse palmoplantar keratoderma. Krt9-/- mice exhibit hyperpigmented calluses on the major stress-bearing footpads that form, progress, and slough off in a precise cyclical fashion (Fu et al., 2014), and thus offer a useful model to study the pathophysiology of EPPK related to KRT9/Krt9 mutations. Previously, our laboratory has shown that oxidative stress associated with hypoactive NRF2, a transcription factor that r...
The skin provides an efficient permeability barrier and protects from microbial invasion and oxidati...
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacologica...
Palmoplantar keratoderma is a hallmark of pachyonychia congenita (PC) and focal non-epidermolytic pa...
Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the supraba...
Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the supraba...
Palmoplantar keratodermas (PPK) are a group of rare skin disorders characterized by abnormal thicken...
This thesis presents novel insight into the pathophysiology of palmoplantar keratoderma and previous...
Background/Aims: Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant genodermatos...
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacologica...
Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice SCHÄFER, Mat...
Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing sites of...
The skin provides an efficient permeability barrier and protects from microbial invasion and oxidati...
AbstractKeratins form an intracellular keratin filament network in keratinocytes. Point mutations in...
Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing sites of...
The skin provides an efficient permeability barrier and protects from microbial invasion and oxidati...
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacologica...
Palmoplantar keratoderma is a hallmark of pachyonychia congenita (PC) and focal non-epidermolytic pa...
Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the supraba...
Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the supraba...
Palmoplantar keratodermas (PPK) are a group of rare skin disorders characterized by abnormal thicken...
This thesis presents novel insight into the pathophysiology of palmoplantar keratoderma and previous...
Background/Aims: Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant genodermatos...
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacologica...
Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice SCHÄFER, Mat...
Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing sites of...
The skin provides an efficient permeability barrier and protects from microbial invasion and oxidati...
AbstractKeratins form an intracellular keratin filament network in keratinocytes. Point mutations in...
Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing sites of...
The skin provides an efficient permeability barrier and protects from microbial invasion and oxidati...
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacologica...
Palmoplantar keratoderma is a hallmark of pachyonychia congenita (PC) and focal non-epidermolytic pa...