BACKGROUND & AIMS: The intestinal immune system is tightly regulated to prevent responses against the many nonpathogenic antigens in the gut. Transforming growth factor (TGF)-β is a cytokine that maintains intestinal homeostasis, in part by inducing Foxp3(+) regulatory T cells (Tregs) that suppress immune responses. TGF-β is expressed at high levels in the gastrointestinal tract as a latent complex that must be activated. However, the pathways that control TGF-β activation in the intestine are poorly defined. We investigated the cellular and molecular pathways that control activation of TGF-β and induction of Foxp3(+) Tregs in the intestines of mice to maintain immune homeostasis. METHODS: Subsets of intestinal dendritic cells (DCs) were ex...
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflam...
The gastrointestinal tract is replete with commensal microbes and dietary nutrients that provide hom...
SummaryTolerance to food antigen manifests in the absence and/or suppression of antigen-specific imm...
Background & AimsThe intestinal immune system is tightly regulated to prevent responses against the ...
CD103+CD11b+ dendritic cells (DCs) are unique to the intestine, but the factors governing their diff...
CD103(+)CD11b(+) dendritic cells (DCs) are unique to the intestine, but the factors governing their ...
CD4+CD25+Foxp3+ regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune res...
Intestinal dendritic cells (DCs) have been shown to display specialized functions, including the abi...
DoctorFoxp3+ regulatory T cells (Tregs) are critical for the maintenance of mucosal tolerance as wel...
In order to maintain immune homeostasis, the intestinal immune system has evolved redundant regulato...
AbstractTo maintain a quiescent gut microenvironment, proper regulation of immune responses initiate...
Foxp3(+) regulatory T (T reg) cells play a key role in controlling immune pathological re actions. M...
The intestinal mucosa presents a huge surface area to the external environment and the intestinal im...
Objective: In mice, a subpopulation of gut dendritic cells (DCs) expressing CD103 drives the develop...
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflam...
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflam...
The gastrointestinal tract is replete with commensal microbes and dietary nutrients that provide hom...
SummaryTolerance to food antigen manifests in the absence and/or suppression of antigen-specific imm...
Background & AimsThe intestinal immune system is tightly regulated to prevent responses against the ...
CD103+CD11b+ dendritic cells (DCs) are unique to the intestine, but the factors governing their diff...
CD103(+)CD11b(+) dendritic cells (DCs) are unique to the intestine, but the factors governing their ...
CD4+CD25+Foxp3+ regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune res...
Intestinal dendritic cells (DCs) have been shown to display specialized functions, including the abi...
DoctorFoxp3+ regulatory T cells (Tregs) are critical for the maintenance of mucosal tolerance as wel...
In order to maintain immune homeostasis, the intestinal immune system has evolved redundant regulato...
AbstractTo maintain a quiescent gut microenvironment, proper regulation of immune responses initiate...
Foxp3(+) regulatory T (T reg) cells play a key role in controlling immune pathological re actions. M...
The intestinal mucosa presents a huge surface area to the external environment and the intestinal im...
Objective: In mice, a subpopulation of gut dendritic cells (DCs) expressing CD103 drives the develop...
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflam...
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflam...
The gastrointestinal tract is replete with commensal microbes and dietary nutrients that provide hom...
SummaryTolerance to food antigen manifests in the absence and/or suppression of antigen-specific imm...