This book is intended to fill a gap in the available literature on the development and application of dynamic simulation models. It deals with issues of model quality and, more specifically, with the processes of testing, verification and validation. Since simulation models can never be proved to be “valid” in any absolute sense, the topic of model testing inevitably involves subjective issues and often a trade-off between accuracy, cost and practical issues concerning the intended use of the model. The emphasis within the book is on continuous system simulation problems and case studies are used to provide examples from engineering and physiology. Supplementary material is available through the publisher’s website. This book is lone of a s...