Responding to R-Spondin: Slit2 potentiates intestinal regeneration
- Phesse, Toby J.
- Sansom, Owen J.
Publication date
November 2013
DOI Publisher
Elsevier BV ISSN
1934-5909 Citation count (estimate)
3Abstract
Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature ( Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery
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