Add to ORKGSBDS protein (deficient in the inherited leukemia-predisposition disorder Shwachman-Diamond syndrome) and the GTPase EFL1 (an EF-G homolog) activate nascent 60S ribosomal subunits for translation by catalyzing eviction of the antiassociation factor eIF6 from nascent 60S ribosomal subunits. However, the mechanism is completely unknown. Here, we present cryo-EM structures of human SBDS and SBDS-EFL1 bound to Dictyostelium discoideum 60S ribosomal subunits with and without endogenous eIF6. SBDS assesses the integrity of the peptidyl (P) site, bridging uL16 (mutated in T-cell acute lymphoblastic leukemia) with uL11 at the P-stalk base and the sarcin-ricin loop. Upon EFL1 binding, SBDS is repositioned around helix 69, thus facilitating a conform...
Abstract The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by muta...
Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease characterized by growth retardati...
The Shwachman-Diamond Syndrome (SDS) is a disorder arising from mutations in the genes encoding for ...
International audienceSBDS protein (deficient in the inherited leukemia-predisposition disorder Shwa...
Protein synthesis is a cyclical process consisting of translation initiation, elongation, terminatio...
Here we discuss the function of eukaryotic initiation factor 6 (eIF6; Tif6 in yeast). eIF6 binds 60S...
Shwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marrow failure and predisp...
International audienceShwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marr...
For the final step of the maturation of the ribosome, the nascent 40S and 60S subunits are exported ...
International audienceIndirect somatic genetic rescue (SGR) of a germline mutation is thought to be ...
Genetic and biochemical studies demonstrate that eIF6 controls the availability of 60S ribosomal sub...
International audienceRibosome biogenesis is orchestrated by the action of several accessory factors...
Mutations that target the ubiquitous process of ribosome assembly paradoxically cause diverse tissue...
Abstract The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by muta...
Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease characterized by growth retardati...
The Shwachman-Diamond Syndrome (SDS) is a disorder arising from mutations in the genes encoding for ...
International audienceSBDS protein (deficient in the inherited leukemia-predisposition disorder Shwa...
Protein synthesis is a cyclical process consisting of translation initiation, elongation, terminatio...
Here we discuss the function of eukaryotic initiation factor 6 (eIF6; Tif6 in yeast). eIF6 binds 60S...
Shwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marrow failure and predisp...
International audienceShwachman-Diamond syndrome (SDS) is a recessive disorder typified by bone marr...
For the final step of the maturation of the ribosome, the nascent 40S and 60S subunits are exported ...
International audienceIndirect somatic genetic rescue (SGR) of a germline mutation is thought to be ...
Genetic and biochemical studies demonstrate that eIF6 controls the availability of 60S ribosomal sub...
International audienceRibosome biogenesis is orchestrated by the action of several accessory factors...
Mutations that target the ubiquitous process of ribosome assembly paradoxically cause diverse tissue...
Abstract The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by muta...
Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease characterized by growth retardati...
The Shwachman-Diamond Syndrome (SDS) is a disorder arising from mutations in the genes encoding for ...