Type I interferon response in bovine endometrial cells co-cultured with peripheral blood mononuclear cells

Embryonic loss is an issue that livestock producers are faced with worldwide. This particular research assesses one aspect of the role that immune cells play in embryonic survival, more specifically, the interaction between peripheral blood mononuclear cells and bovine endometrial cells, and their connection to interferon-stimulated genes. Peripheral blood mononuclear cells were taken from three different cows and were cultured with bovine endometrial cells. Some of the cultures contained interferon, and some did not. After incubation, results showed that the immune cells did not increase interferon-stimulated genes, and are stimulating a pathway in the response to pregnancy that is currently unknown