Dynamic adoption of anergy by antigen-exhausted CD4<sup>+</sup> T cells.
- Trefzer, A.
- Kadam, P.
- Wang, S.H.
- Pennavaria, S.
- Lober, B.
- Akçabozan, B.
- Kranich, J.
- Brocker, T.
- Nakano, N.
- Irmler, M.
- Beckers, J.
- Straub, T.
- Obst, R.
DOIAbstract
In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap
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