The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the greatest obstacle in the current efforts to treat and cure HIV infection. Recent efforts to purge out latently infected memory CD4+ T-cells using latency-reversing agents have failed in clinical trials. This review discusses the epigenetic and non-epigenetic mechanisms of HIV latency control, major limitations of the current approaches of using latency-reversing agents to reactivate HIV latency in resting CD4+ T-cells, and potential solutions to these limitations
Eradication of human immunodeficiency virus (HIV) in infected individuals is currently not possible ...
HIV cure is impeded by the persistence of a strenuous reservoir of latent but replication competent ...
Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Rea...
The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the grea...
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at incr...
Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, b...
Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual...
Persistence of transcriptionally silent replication competent HIV-1 is a major barrier to clearance ...
Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T ...
Background: Latent HIV-1 reservoirs are identified as one of the major challenges to achieve HIV-1 c...
Despite effective treatment, HIV is not completely eliminated from the infected organism because of ...
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt vir...
Abstract The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication ...
AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still una...
When HIV infects host immune cells, it inserts its genetic material into their DNA enabling the viru...
Eradication of human immunodeficiency virus (HIV) in infected individuals is currently not possible ...
HIV cure is impeded by the persistence of a strenuous reservoir of latent but replication competent ...
Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Rea...
The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the grea...
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at incr...
Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, b...
Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual...
Persistence of transcriptionally silent replication competent HIV-1 is a major barrier to clearance ...
Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T ...
Background: Latent HIV-1 reservoirs are identified as one of the major challenges to achieve HIV-1 c...
Despite effective treatment, HIV is not completely eliminated from the infected organism because of ...
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt vir...
Abstract The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication ...
AIDS first emerged decades ago; however, its cure, i.e., eliminating all virus sources, is still una...
When HIV infects host immune cells, it inserts its genetic material into their DNA enabling the viru...
Eradication of human immunodeficiency virus (HIV) in infected individuals is currently not possible ...
HIV cure is impeded by the persistence of a strenuous reservoir of latent but replication competent ...
Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Rea...