Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s)
- Basu, K.
- Baral, A.
- Basak, S.
- Dehsorkhi, Ashkan
- Nanda, J.
- Bhunia, D.
- Ghosh, S.
- Castelletto, Valeria
- Hamley, Ian W.
- Banerjee, A.
Publication date
March 2016
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
1359-7345 Citation count (estimate)
21Abstract
Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating D-amino acid residues, indicating their potential use for drug delivery in the future
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