The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.
- Spalton, J C
- Mori, J
- Pollitt, A Y
- Hughes, C E
- Eble, J A
- Watson, S P
Publication date
July 2009
DOI ISSN
1538-7933 Citation count (estimate)
60Abstract
The inhibitory effect of R406 provides direct evidence of a role for Syk in GPVI, CLEC-2 and integrin alphaIIbbeta3 signaling in human platelets. Further, the results demonstrate a critical role for Syk in mediating tyrosine phosphorylation of CLEC-2, suggesting a novel model in which both Src and Syk kinases regulate tyrosine phosphorylation of the C-type lectin receptor leading to platelet activation
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