Biomolecules altering the lipid molecular shape in model non-lamellar membranes

Intracellular membranes exhibit complex, highly dynamic and non-lamellar morphologies.1 Structural resemblance of such membranes with bicontinuous cubic and hexagonal lipid phases has been recognised in past two decades.2 However, principles behind their dynamic organization and structural roles in cellular processes still remain elusive. Model membrane systems like liposomes, planar lipid bilayers and micelles have been largely used to interact various biomolecules to determine structures and functions of biomembrane systems