International audienceINTRODUCTION: Cholangiocarcinoma (CCA) is a rare, deadly cancer which is characterized by an abundant desmoplastic stroma. Late diagnoses and limited available effective treatments are major problems with this malignancy. Targeting of the tumor microenvironment (TME) has emerged as a potential therapeutic strategy. AREAS COVERED: In this review, we describe the role of the various compartments of the TME in CCA and focus on the preclinical rationale for the development of innovative therapies. Relevant literature was identified by a PubMed search covering the last decade (2010-2020). EXPERT OPINION: Low efficacy of surgery and cytotoxic chemotherapy emphasizes the need for new therapeutic strategies and companion bioma...
Cholangiocarcinoma (CCA) is a type of biliary tract cancer emerging from the biliary tree. CCA is th...
Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cel...
Introduction: Cholangiocarcinoma (CCA) is a liver cancer derived from the biliary tree with a less t...
Cholangiocarcinoma (CCA) represents a diverse group of epithelial cancers associated with the biliar...
Cholangiocarcinoma (CCAs) may be defined as tumors that derived from the biliary tree with the diffe...
SummaryClinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CC...
Tumor microenvironment is a complex, multicellular functional compartment that, particularly when as...
Cholangiocarcinoma (CCA), an aggressive tumor originating from both intra-and extra-hepatic biliary ...
Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy of the biliary tree. A typica...
Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features of cholan...
Tumour microenvironment is a complex, multicellular functional compartment that, particularly when a...
Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in th...
Cholangiocarcinoma is one of the epithelial cancers with the poorest prognosis and the narrowest the...
Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in th...
Background: Cholangiocarcinoma (CCA) is a rare cancer of the bile ducts but has been increasing in i...
Cholangiocarcinoma (CCA) is a type of biliary tract cancer emerging from the biliary tree. CCA is th...
Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cel...
Introduction: Cholangiocarcinoma (CCA) is a liver cancer derived from the biliary tree with a less t...
Cholangiocarcinoma (CCA) represents a diverse group of epithelial cancers associated with the biliar...
Cholangiocarcinoma (CCAs) may be defined as tumors that derived from the biliary tree with the diffe...
SummaryClinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CC...
Tumor microenvironment is a complex, multicellular functional compartment that, particularly when as...
Cholangiocarcinoma (CCA), an aggressive tumor originating from both intra-and extra-hepatic biliary ...
Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy of the biliary tree. A typica...
Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features of cholan...
Tumour microenvironment is a complex, multicellular functional compartment that, particularly when a...
Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in th...
Cholangiocarcinoma is one of the epithelial cancers with the poorest prognosis and the narrowest the...
Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in th...
Background: Cholangiocarcinoma (CCA) is a rare cancer of the bile ducts but has been increasing in i...
Cholangiocarcinoma (CCA) is a type of biliary tract cancer emerging from the biliary tree. CCA is th...
Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cel...
Introduction: Cholangiocarcinoma (CCA) is a liver cancer derived from the biliary tree with a less t...