Seven new loci associated with age-related macular degeneration
- Fritsche, LG
- Chen, W
- Schu, M
- Yaspan, BL
- Yu, Y
- Thorleifsson, G
- Zack, DJ
- Arakawa, S
- Cipriani, V
- Ripke, S
- Igo, RP
- Buitendijk, GHS
- Sim, X
- Weeks, DE
- Guymer, RH
- Merriam, JE
- Francis, PJ
- Hannum, G
- Agarwal, A
- Armbrecht, AM
- Audo, I
- Aung, T
- Barile, GR
- Benchaboune, M
- Bird, AC
- Bishop, PN
- Branham, KE
- Brooks, M
- Brucker, AJ
- Cade, WH
- Cain, MS
- Campochiaroll, PA
- Chan, C-C
- Cheng, C-Y
- Chew, EY
- Chin, KA
- Chowers, I
- Clayton, DG
- Cojocaru, R
- Conley, YP
- Cornes, BK
- Daly, MJ
- Dhillon, B
- Edwards, A
- Evangelou, E
- Fagemess, J
- Ferreyra, HA
- Friedman, JS
- Geirsdottir, A
- George, RJ
- Gieger, C
- Gupta, N
- Hagstrom, SA
- Harding, SP
- Haritoglou, C
- Heckenlively, JR
- Hoz, FG
- Hughes, G
- Ioannidis, JPA
- Ishibashi, T
- Joseph, P
- Jun, G
- Kamatani, Y
- Katsanis, N
- Keilhauer, CN
- Khan, JC
- Kim, IK
- Kiyohara, Y
- Klein, BEK
- Klein, R
- Kovach, JL
- Kozak, I
- Lee, CJ
- Lee, KE
- Lichtner, P
- Lotery, AJ
- Meitinger, T
- Mitchell, P
- Mohand-Saied, S
- Moore, AT
- Morgan, DJ
- Morrison, MA
- Myers, CE
- Naj, AC
- Nakamura, Y
- Okada, Y
- Orlin, A
- Ortube, MC
- Othman, MI
- Pappas, C
- Park, KH
- Pauer, GJT
- Peachey, NS
- Poch, O
- Priya, RR
- Reynolds, R
- Richardson, AJ
- Ripp, R
- Rudolph, G
- Ryu, E
- Sahel, J-A
- Schaumberg, DA
- Scholl, HPN
- Schwartz, SG
- Scott, WK
- Shahid, H
- Sigurdsson, H
- Silvestri, G
- Sivakumaran, TA
- Smith, RT
- Sobrin, L
- Souied, EH
- Stambolian, DE
- Stefansson, H
- Sturgill-Short, GM
- Takahashi, A
- Tosakulwong, N
- Truitt, BJ
- Tsironi, EE
- Uitterlinden, AG
- van Duijn, CM
- Vijaya, L
- Vingerling, JR
- Vithana, EN
- Webster, AR
- Wichmann, H-E
- Winkler, TW
- Wong, TY
- Wright, AF
- Zelenika, D
- Zhang, M
- Zhao, L
- Zhang, K
- Klein, ML
- Hageman, GS
- Lathrop, GM
- Stefansson, K
- Allikmets, R
- Baird, PN
- Gorin, MB
- Wang, JJ
- Klaver, CCW
- Seddon, JM
- Pericak-Vance, MA
- Iyengar, SK
- Yates, JRW
- Swaroop, A
- Weber, BHF
- Kubo, M
- DeAngelis, MM
- Leveillard, T
- Thorsteinsdottir, U
- Haines, JL
- Farrer, LA
- Heid, IM
- Abecasis, GR
DOIAbstract
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotyp...
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