Prospective Surveillance of Invasive Group A Streptococcal Disease, Fiji, 2005-2007
- Steer, AC
- Jenney, A
- Kado, J
- Good, MF
- Batzloff, M
- Waqatakirewa, L
- Mullholland, EK
- Carapetis, JR
DOIAbstract
We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtype...
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