The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(-)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κB transcription factor required for nTreg differentiation, we establish that c-Rel regulates both of these developmental steps. c-Rel controls the generation of nTreg precursors via a haplo-insufficient mechanism, indicating that this step is highly sensitive to c-Rel levels. However, maintenance of c-Rel in an inactive state in nTreg precursors demonstrates that it is not required for a constitutive function in these cells. While the subsequent ...
CD4{u207A} T lymphocytes play an important role in the adaptive immune response that protects the ho...
AbstractMultiple members of the NF-κB/Rel protein family are induced during B cell differentiation a...
In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the tra...
The development of natural Foxp3+ CD4 regulatory T cells (nTregs) proceeds via two steps that involv...
The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple ...
The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple ...
Next to the classical developmental route, in which first CD25 and subsequently Foxp3 are induced to...
During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory ...
Foxp3 expressing CD4⁺ regulatory T cells (Tregs) are critical for the maintenance of immune homeosta...
During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory ...
SummaryRegulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 ex...
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease involving ef...
International audienceRegulatory T cells (Tregs) play a major role in immune homeostasis and in the ...
Expression of the lineage-specific DNA-binding factor Foxp3 controls the development and function of...
The transcription factors of the Rel/NF-κB family function as key regulators of innate and adoptive ...
CD4{u207A} T lymphocytes play an important role in the adaptive immune response that protects the ho...
AbstractMultiple members of the NF-κB/Rel protein family are induced during B cell differentiation a...
In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the tra...
The development of natural Foxp3+ CD4 regulatory T cells (nTregs) proceeds via two steps that involv...
The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple ...
The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple ...
Next to the classical developmental route, in which first CD25 and subsequently Foxp3 are induced to...
During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory ...
Foxp3 expressing CD4⁺ regulatory T cells (Tregs) are critical for the maintenance of immune homeosta...
During thymopoiesis, a unique program of gene expression promotes the development of CD4 regulatory ...
SummaryRegulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 ex...
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease involving ef...
International audienceRegulatory T cells (Tregs) play a major role in immune homeostasis and in the ...
Expression of the lineage-specific DNA-binding factor Foxp3 controls the development and function of...
The transcription factors of the Rel/NF-κB family function as key regulators of innate and adoptive ...
CD4{u207A} T lymphocytes play an important role in the adaptive immune response that protects the ho...
AbstractMultiple members of the NF-κB/Rel protein family are induced during B cell differentiation a...
In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the tra...