Glucocorticoids are commonly used to prevent chemotherapy-induced nausea and vomiting despite a lack of understanding of their direct effect on cancer progression. Recent studies suggest that glucocorticoids inhibit cancer cell migration. However, this action has not been investigated in estrogen receptor (ER)-negative breast tumour cells, although activation of the glucocorticoid receptor (GR) is associated with a worse prognosis in ER-negative breast cancers. In this study we have explored the effect of glucocorticoids on the migration of the ER-negative MDA-MB-231 human breast tumour cell line and the highly metastatic MDA-MB-231-HM.LNm5 cell line that was generated through in vivo cycling. We show for the first time that glucocorticoids...
Purpose: Glucocorticoids (GCs) are often administered prior to any chemotherapeutics to prevent the ...
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted syste...
Background: Approximately 75% of all breast cancer diagnoses are oestrogen receptor a (ERa) positive...
Glucocorticoids (GCs) are stress hormones that play multiple roles in the regulation of cancer cell ...
Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the ...
[[abstract]]Glucocorticoids have been used in clinical oncology for over half of the century. The cl...
BACKGROUND: Glucocorticoids are widely used for cancer patients, although they can reduce the effica...
Diversity within or between tumours and metastases (known as intra-patient tumour heterogeneity) tha...
International audienceBreast cancer (BC) is one of the most common cancers in women worldwide. Even ...
Glucocorticoids play a major role in attenuation of the inflammatory response and they are useful in...
The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily of transcription fa...
The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid...
Glucocorticoids (GCs) are used in the treatment of cancer to induce programmed cell death in the tra...
Glucocorticoids (GCs) are often used as an adjuvant therapy to reduce the adverse effects of chemoth...
BACKGROUND: The microenvironment and stress factors like glucocorticoids have a strong influence on ...
Purpose: Glucocorticoids (GCs) are often administered prior to any chemotherapeutics to prevent the ...
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted syste...
Background: Approximately 75% of all breast cancer diagnoses are oestrogen receptor a (ERa) positive...
Glucocorticoids (GCs) are stress hormones that play multiple roles in the regulation of cancer cell ...
Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the ...
[[abstract]]Glucocorticoids have been used in clinical oncology for over half of the century. The cl...
BACKGROUND: Glucocorticoids are widely used for cancer patients, although they can reduce the effica...
Diversity within or between tumours and metastases (known as intra-patient tumour heterogeneity) tha...
International audienceBreast cancer (BC) is one of the most common cancers in women worldwide. Even ...
Glucocorticoids play a major role in attenuation of the inflammatory response and they are useful in...
The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily of transcription fa...
The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid...
Glucocorticoids (GCs) are used in the treatment of cancer to induce programmed cell death in the tra...
Glucocorticoids (GCs) are often used as an adjuvant therapy to reduce the adverse effects of chemoth...
BACKGROUND: The microenvironment and stress factors like glucocorticoids have a strong influence on ...
Purpose: Glucocorticoids (GCs) are often administered prior to any chemotherapeutics to prevent the ...
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted syste...
Background: Approximately 75% of all breast cancer diagnoses are oestrogen receptor a (ERa) positive...