Alcohol affects many neurochemical processes, causing long-lasting changes in both the adult and developing brain. The Jak-Stat transcriptional activation pathway plays a role in the control of neuronal proliferation, survival and differentiation, but the effects of ethanol on the system have not been fully elucidated. The goal of this project was to define the effects of acute and subchronic ethanol exposure on the expression of proteins in the Jak-Stat pathway, using cultured NG108-15 cells, and in addition, to test the hypothesis that these effects are mediated through the NMDA receptor. I found that ethanol dose-dependently decreased Jak2 and Stat3 following subchronic exposure of NG108-15 in culture. Acute ethanol exposure cau...
Chronic alcohol exposure can cause dramatic behavioral alterations, including increased anxiety-like...
Background: Alcohol exerts its behavioural and neurophysiological effects by acting on multiple neur...
Adverse effect of alcohol on neural function has been well documented. Especially, the teratogenic e...
Abstract: Long-term alcohol exposure may lead to development of alcohol dependence in consequence of...
Primary cultures of cerebellar granule cells were used to investigate the effects of acute and chron...
This study demonstrates a method for studying the effects of ethanol on transcription mediated by ac...
International audienceChronic exposure to ethanol leads to adaptive responses in neurons, including ...
This study describes the effects of acute ethanol exposure on the mRNA levels of c-jun,junB and junD...
The expression of c-fos mRNA in rat brain was induced by intraperitoneal (ip) administration of N-me...
Hippocampal network oscillations at gamma band frequency (γ, 30–80 Hz) are closely associated with h...
Background: Alcoholism is associated with shrinkage of brain tissue and reduction in the number of n...
Although ethanol intoxication is reported to be a complicating factor in traumatic brain injury, som...
The hippocampal N-methyl-D-aspartate receptor (NMDAR) ac-tivity plays important roles in cognition a...
BACKGROUND: This study evaluated the dose-related ethanol-like subjective effects of the N-methyl-D-...
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central...
Chronic alcohol exposure can cause dramatic behavioral alterations, including increased anxiety-like...
Background: Alcohol exerts its behavioural and neurophysiological effects by acting on multiple neur...
Adverse effect of alcohol on neural function has been well documented. Especially, the teratogenic e...
Abstract: Long-term alcohol exposure may lead to development of alcohol dependence in consequence of...
Primary cultures of cerebellar granule cells were used to investigate the effects of acute and chron...
This study demonstrates a method for studying the effects of ethanol on transcription mediated by ac...
International audienceChronic exposure to ethanol leads to adaptive responses in neurons, including ...
This study describes the effects of acute ethanol exposure on the mRNA levels of c-jun,junB and junD...
The expression of c-fos mRNA in rat brain was induced by intraperitoneal (ip) administration of N-me...
Hippocampal network oscillations at gamma band frequency (γ, 30–80 Hz) are closely associated with h...
Background: Alcoholism is associated with shrinkage of brain tissue and reduction in the number of n...
Although ethanol intoxication is reported to be a complicating factor in traumatic brain injury, som...
The hippocampal N-methyl-D-aspartate receptor (NMDAR) ac-tivity plays important roles in cognition a...
BACKGROUND: This study evaluated the dose-related ethanol-like subjective effects of the N-methyl-D-...
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central...
Chronic alcohol exposure can cause dramatic behavioral alterations, including increased anxiety-like...
Background: Alcohol exerts its behavioural and neurophysiological effects by acting on multiple neur...
Adverse effect of alcohol on neural function has been well documented. Especially, the teratogenic e...
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