Using a combination of polymerase chain reaction (PCR) and genomic library screening, a human (h) gene for a subtype of the somatostatin (SST) receptor (SSTR), termed hSSTR5, was cloned. Human SSTR5 consists of a 363-residue polypeptide exhibiting a putative seven-transmembrane domain topology typical of G protein-coupled receptors. The receptor displays 45% to 52% sequence identity to the other four cloned hSSTR subtype genes (SSTRl-SSTR4). Pharmacological analysis of hSSTR5 revealed that this receptor bound SST-28 with a 12.6-fold greater affinity compared with SST-14, indicating that hSSTR5, unlike the other four SSTR subtypes, is SST-28 selective. hSSTR5 was negatively coupled to adenylyl cyclase via a pertussis toxin-sensitive G protei...
Neuroendocrine tumours (NETs) may occur at many sites in the body although the majority occur within...
The role of somatostatin (SS) receptor subtype 1 (SSTR(1)) in mediating the inhibitory effect of SS ...
Background: Somatostatin is a tetradecapeptide exerting inhibitory action on endocrine and exocrine ...
The role of somatostatin receptor subtypes 2 and 5 (SSTR2 and SSTR5) in determining the secretory an...
AbstractWe report here on the cloning of a human intronless gene encoding a member of the G-protein ...
We have isolated a gene coding for a fourth human somatostatin (somatotropin release-inhibiting fact...
Somatostatin (SRIF), a hypothalamic inhibitor of pituitary growth hormone (GH) and thyroid-stimulati...
Somatostatin exerts antisecretive and antiproliferative effects on different endocrine cells by acti...
Somatostatin (SRIF) analogs interacting with SRIF receptor subtype (SSTR) 2 and SSTR5 are known to r...
The physiological actions of somatostatin-14 (SRIF: somatotrophin release inhibitory factor) recepto...
AbstractWe report the identification of a gene, named SLC-11, encoding a novel G protein-coupled rec...
The development of somatostatin analogs for the treatment of pituitary Cushing’s disease has been ba...
L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/The physiological action...
The physiological actions of somatostatin-14 (SRIF: somatotrophin release inhibitory factor) recepto...
Somatostatin (SST) exerts inhibitory effects on hormone secretion and cell proliferation by interact...
Neuroendocrine tumours (NETs) may occur at many sites in the body although the majority occur within...
The role of somatostatin (SS) receptor subtype 1 (SSTR(1)) in mediating the inhibitory effect of SS ...
Background: Somatostatin is a tetradecapeptide exerting inhibitory action on endocrine and exocrine ...
The role of somatostatin receptor subtypes 2 and 5 (SSTR2 and SSTR5) in determining the secretory an...
AbstractWe report here on the cloning of a human intronless gene encoding a member of the G-protein ...
We have isolated a gene coding for a fourth human somatostatin (somatotropin release-inhibiting fact...
Somatostatin (SRIF), a hypothalamic inhibitor of pituitary growth hormone (GH) and thyroid-stimulati...
Somatostatin exerts antisecretive and antiproliferative effects on different endocrine cells by acti...
Somatostatin (SRIF) analogs interacting with SRIF receptor subtype (SSTR) 2 and SSTR5 are known to r...
The physiological actions of somatostatin-14 (SRIF: somatotrophin release inhibitory factor) recepto...
AbstractWe report the identification of a gene, named SLC-11, encoding a novel G protein-coupled rec...
The development of somatostatin analogs for the treatment of pituitary Cushing’s disease has been ba...
L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/The physiological action...
The physiological actions of somatostatin-14 (SRIF: somatotrophin release inhibitory factor) recepto...
Somatostatin (SST) exerts inhibitory effects on hormone secretion and cell proliferation by interact...
Neuroendocrine tumours (NETs) may occur at many sites in the body although the majority occur within...
The role of somatostatin (SS) receptor subtype 1 (SSTR(1)) in mediating the inhibitory effect of SS ...
Background: Somatostatin is a tetradecapeptide exerting inhibitory action on endocrine and exocrine ...