The aim of these studies was to characterize the involvement of the serine/threonine phosphatases 1 and 2A in cholinergic nerve terminal function. This was studied in rat hippocampal formation using the specific inhibitors of phosphatases I and 2A, calyculin A (Cal A) and okadaic acid (OKA).The first set of experiments demonstrated that treatment with OKA or Cal A reduced tissue ACh content, choline acetyltransferase (ChAT) activity, choline uptake and [3H] ACh synthesis in rat hippocampal formation, but spontaneous ACh release was not affected. Thus, it is clear that phosphatase activity plays a role in presynaptic central cholinergic nerve terminal function, particularly in the regulation of ACh synthesis. The mechanisms that regulate ACh...
A form of CAT-like activity was found bound present in rat brain synaptosomal membranes which could ...
Acetylcholine (ACh) is a neurotransmitter widely diffused in central, peripheral, autonomic and ente...
The effects of various neuroleptics and of apomorphine on the metabolism of ACh were examined in the...
Choline acetyltransferase (ChAT; EC 2.3.1.6) catalyses the biosynthesis of acetylcholine (ACh) from ...
This study examined the possibility that membrane phospholipids might be a source of choline used fo...
The roles of cyclic AMP and protein kinase A in regulating high-affinity choline uptake under restin...
Using the phosphatase inhibitor calyculin A, we have examined the influence of phosphorylation on sy...
Using the phosphatase inhibitor calyculin A, we have examined the influence of phosphorylation on sy...
Choline (Ch) is involved in relevant neurochemical processes. It is the precursor and metabolite of ...
The influence of one week treatment with the choline-containing phospholipids cytidine-5'-diphosphoc...
SUMMARY: The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release f...
The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release from strep...
The effect of β-amyloid aggregates on activity of choline acetyltransferase (ChAT) which is respons...
Cholinergic hypofunction is a trait of Alzheimer's disease and vascular dementia and countering it i...
Cholinergic hypofunction is a trait of Alzheimer's disease and vascular dementia and countering it i...
A form of CAT-like activity was found bound present in rat brain synaptosomal membranes which could ...
Acetylcholine (ACh) is a neurotransmitter widely diffused in central, peripheral, autonomic and ente...
The effects of various neuroleptics and of apomorphine on the metabolism of ACh were examined in the...
Choline acetyltransferase (ChAT; EC 2.3.1.6) catalyses the biosynthesis of acetylcholine (ACh) from ...
This study examined the possibility that membrane phospholipids might be a source of choline used fo...
The roles of cyclic AMP and protein kinase A in regulating high-affinity choline uptake under restin...
Using the phosphatase inhibitor calyculin A, we have examined the influence of phosphorylation on sy...
Using the phosphatase inhibitor calyculin A, we have examined the influence of phosphorylation on sy...
Choline (Ch) is involved in relevant neurochemical processes. It is the precursor and metabolite of ...
The influence of one week treatment with the choline-containing phospholipids cytidine-5'-diphosphoc...
SUMMARY: The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release f...
The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release from strep...
The effect of β-amyloid aggregates on activity of choline acetyltransferase (ChAT) which is respons...
Cholinergic hypofunction is a trait of Alzheimer's disease and vascular dementia and countering it i...
Cholinergic hypofunction is a trait of Alzheimer's disease and vascular dementia and countering it i...
A form of CAT-like activity was found bound present in rat brain synaptosomal membranes which could ...
Acetylcholine (ACh) is a neurotransmitter widely diffused in central, peripheral, autonomic and ente...
The effects of various neuroleptics and of apomorphine on the metabolism of ACh were examined in the...