Studies on the incubation of brain sub-cellular particles under various conditions which affect the release of materials with acetylcholine-like activity.

The synthesis of acetylcholine (ACh) was achieved by Baeyer (1) as early as 1867. However, there was complete lack of interest in this compound for almost forty years. Then, in 1906, Hunt and Taveau (2) displayed its marked depressor effects on the heart and blood pressure and they further showed that these pharmacological effects could be abolished by the administration of atropine. [...