Studies on renin-angiotensin system in various human and physiological and pathological states.

The corner-stone of the Renin-Angiotensin System was laid down almost seven decades ago when Tigerstedt and Bergman gave the name "Renin" to the pressor substance they had discovered in kidney extracts (1). However, this discovery was forgotten for many years before its importance was recognized. This recognition came in 1934 when Goldblatt demonstrated the role of the kidney in the pathogenesis of a certain type of hypertension (2) and especially after it appeared that the renal pressor substance might be involved in the pathogenesis of experimental and human hypertension. Thereafter, for many years, the renin-angiotensin system became closely and almost exclusively associated with the field of hypertension. [...