Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
- Clarke, Robert
- Bennett, Derrick A.
- Parish, Sarah
- Verhoef, Petra
- Dötsch-Klerk, Mariska
- Lathrop, Mark
- Xu, Peng
- Nordestgaard, Børge G.
- Hopewell, Jemma C.
- Saleheen, Danish
- Tanaka, Toshihiro
- Anand, Sonia S.
- Chambers, John C.
- Ouwehand, Willem H.
- Yamada, Yoshiji
- Elbers, Clara
- Peters, Bas
- Stewart, Alexandre F. R.
- Thorand, Barbara
- Yusef, Salim
- Engert, James C.
- Kooner, Jaspal
- Danesh, John
- Watkins, Hugh
- Samani, Nilesh J.
- Collins, Rory
DOIAbstract
Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so “Mendelian randomization” studies using this variant as an instrumental variable could help test causality.[...
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