Objective: Oral squamous cell carcinoma (OSCC) is known to aggressively invade bone in a complex process that remains vague and poorly understood in many aspects. It is known that OSCC recruits osteoclasts, bone cells uniquely capable of bone destruction. The goal of this study was to assess the effects of soluble factors produced by OSCC on osteoclasts formation and responsiveness of bisphosphonates.Methods: BHY is the human cell line originally isolated from bone invasive OSCC. BHY OSCC cells were cultured and condition media was collected. Osteoclast formation from mouse murine monocytes RAW 264.7 cells was assessed for both osteoclast number and shape. Bisphosphonate pamidronate was used in concentrations 10-6-10-8 M.Results: BHY CM s...
Bisphosphonates cause osteoclast apoptosis, thus inhibiting bone resorption and reducing bone loss. ...
Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The effect of bi...
PURPOSE: Bisphosphonates are synthetic analogues of pyrophosphate usually used in treating bone dis...
Objective: Bone invasion represent significant problem in managing head and neck cancers, however th...
Bisphosphonates are reported to have an inhibitory effect on bone resorption in vivo and in vitro. T...
Bisphosphonates (BPs) are stable analogues of the Inorganic Pyrophosphate (PPi), an endogenous regul...
Local growth of osteosarcoma involves destruction of host bone by proteolytic mechanisms and/or host...
Bone tissue constitutes a fertile 'soil' for metastatic tumours, notably breast cancer. High concent...
Osteoclastic activation is the ultimate way of bone resorption in neoplasia, induced by the combined...
Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated c...
Introduction: Bisphosphonates (BPs) are chemical analogues related to pyrophosphate; they are well k...
Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective establ...
International audienceBone tumours can be dissociated in two main categories: i) primary bone tumour...
According to the literature, 30-90% of patients with advanced cancer will develop skeletal metastase...
Bone tumours can be dissociated in two main categories: i) primary bone tumours (benign or malignant...
Bisphosphonates cause osteoclast apoptosis, thus inhibiting bone resorption and reducing bone loss. ...
Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The effect of bi...
PURPOSE: Bisphosphonates are synthetic analogues of pyrophosphate usually used in treating bone dis...
Objective: Bone invasion represent significant problem in managing head and neck cancers, however th...
Bisphosphonates are reported to have an inhibitory effect on bone resorption in vivo and in vitro. T...
Bisphosphonates (BPs) are stable analogues of the Inorganic Pyrophosphate (PPi), an endogenous regul...
Local growth of osteosarcoma involves destruction of host bone by proteolytic mechanisms and/or host...
Bone tissue constitutes a fertile 'soil' for metastatic tumours, notably breast cancer. High concent...
Osteoclastic activation is the ultimate way of bone resorption in neoplasia, induced by the combined...
Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated c...
Introduction: Bisphosphonates (BPs) are chemical analogues related to pyrophosphate; they are well k...
Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective establ...
International audienceBone tumours can be dissociated in two main categories: i) primary bone tumour...
According to the literature, 30-90% of patients with advanced cancer will develop skeletal metastase...
Bone tumours can be dissociated in two main categories: i) primary bone tumours (benign or malignant...
Bisphosphonates cause osteoclast apoptosis, thus inhibiting bone resorption and reducing bone loss. ...
Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The effect of bi...
PURPOSE: Bisphosphonates are synthetic analogues of pyrophosphate usually used in treating bone dis...